• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Voglibose

Voglibose

Product ID V5725
Cas No. 83480-29-9
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $97.70 In stock
10 mg $171.30 In stock
25 mg $339.70 In stock
100 mg $1,006.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Voglibose is an inhibitor of α-glucosidase that exhibits anti-diabetic, anti-hyperglycemic, anti-hyperlipidemic, anti-melanogenic, and cardioprotective benefits. In obese mice, voglibose increases plasma levels of glucagon-like peptide 1 (GLP-1), indirectly decreasing activity of DPP4. Additionally, voglibose decreases expression of intracellular adhesion molecule 1 (ICAM-1) and excretion of C-reactive protein (CRP), also decreasing oxidative stress. In clinical studies, voglibose improves body mass index and hemoglobin A(1c) values and decreases hyperlipidemia and hyperglycemia. Inhibition of α-glucosidase also blocks N-glycan modification of tyrosinase, decreasing levels of tyrosinase and melanin. In several animal models of myocardial ischemia/reperfusion, voglibose upregulates phosphorylated Akt and phosphorylated eNOS expression, decreasing myocardial infarction size; this compound may also activate GLP-1 receptors or open mitochondrial K+ (ATP) channels,

Product Info

Cas No.

83480-29-9

Purity

≥99%

Formula

C10H21NO7

Formula Wt.

267.28

Chemical Name

(1S,2S,3R,4S,5S)-5-(1,3-dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol

IUPAC Name

(1S,2S,3R,4S,5S)-5-(1, 3-dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol

Synonym

Glustat; Basen; AO-128; Vocarb; 3,4-dideoxy-4-((2-hydroxy-1-(hydroxymethyl)ethyl)amino)-2-C-(hydroxymethyl)-D-epi-inositol

Melting Point

162 -164 ℃

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

V5725 MSDS PDF

Info Sheet

V5725 Info Sheet PDF

References

Bin BH, Seo J, Yang SH, et al. Novel inhibitory effect of the antidiabetic drug voglibose on melanogenesis. Exp Dermatol. 2013 Aug;22(8):541-6. PMID: 23879813.

Iwasa M, Kobayashi H, Yasuda S, et al. Antidiabetic drug voglibose is protective against ischemia-reperfusion injury through glucagon-like peptide 1 receptors and the phosphoinositide 3-kinase-Akt-endothelial nitric oxide synthase pathway in rabbits. J Cardiovasc Pharmacol. 2010 Jun;55(6):625-34. Erratum in: J Cardiovasc Pharmacol. 2012 Jul;60(1):108. PMID: 20351564.

Kawamori R, Tajima N, Iwamoto Y, et al. Voglibose for prevention of type 2 diabetes mellitus: a randomised, double-blind trial in Japanese individuals with impaired glucose tolerance. Lancet. 2009 May 9;373(9675):1607-14. PMID: 19395079.

Moritoh Y, Takeuchi K, Hazama M. Chronic administration of voglibose, an alpha-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice. J Pharmacol Exp Ther. 2009 May;329(2):669-76. PMID: 19208898.

Satoh N, Shimatsu A, Yamada K, et al. An alpha-glucosidase inhibitor, voglibose, reduces oxidative stress markers and soluble intercellular adhesion molecule 1 in obese type 2 diabetic patients. Metabolism. 2006 Jun;55(6):786-93. PMID: 16713439.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E6231

    (−)-Epicatechin

    Flavanol originally found in Camilla (green tea...

    ≥93%
  • V0275

    [Arg8]-Vasotocin

    Peptide, oxytocin-vasopressin analog.

    ≥95%
  • V3378

    Vitamin B12

    Coenzyme, vitamin found in dairy, meat, eggs, f...

    ≥97%
  • C1176

    CCT-128930

    Pyrrolopyrimidine; Akt inhibitor.

    ≥98%
  • C0020

    Cafestol

    Diterpene found in brewed, unfiltered coffee; F...

    ≥98%
  • D1746

    Deltarasin Hydrochloride Trihydrate

    PDEδ inhibitor.

    ≥99%
  • L8008

    D-Luciferin, firefly, Free Acid

    Heterocyclic light-emitting compound, natural l...

    ≥98%
  • P2400

    Phenethyl Caffeate

    Found in propolis; 5-lipoxygenase inhibitor.

    ≥98%
  • D183745

    Destruxin B

    Cyclic depsipeptide is a secondary metabolite i...

    ≥96%
  • Y1000

    Y27632 Dihydrochloride

    ROCK inhibitor.

    ≥99%
  • A5302

    Anastrozole

    Aromatase inhibitor.

    ≥99%
  • P7056

    Procaterol Hydrochloride

    β2-adrenergic agonist.

    ≥98%
  • U8000

    U-74389G

    Antioxidant shown to improve renal function.

    ≥95%
  • L5870

    Lornoxicam

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • B8274

    Buspirone Hydrochloride

    Azapirone; α1-adrenergic and 5-HT1A partial ag...

    ≥98%
  • C9677

    Cyclocytidine Hydrochloride

    Pyrimidine nucleoside analog; DNA synthesis inh...

    ≥98%
  • I8618

    Ivermectin

    Avermectin; glu-gated Cl- channel activator, Gl...

    ≥95%
  • S0459

    SB-590885

    B-Raf inhibitor.

    ≥97%
  • A5193

    Amygdalin

    Glucoside found in stone fruits and apples.

    ≥98%
  • A5030

    4-Aminophenylphosphate Monosodium

    Alkaline phosphatase substrate used to quantify...

    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only