• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register

U-74389G

Product ID U8000
Cas No. 153190-29-5
Purity ≥95%
Product Unit SizeCostQuantityStock
25 mg $42.90 In stock
100 mg $143.10 Please Inquire
Bulk Quote
Add to Wishlist

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

U-74389G is an antioxidant that exhibits free radical-scavenging protective effects on ischemia/reperfusion injured liver in Wistar rat models. Short-term administration has been shown to improve renal function. It has also been demonstrated to produce an anti-inflammatory activity in the Wistar rat model of colitis.

Product Info

Cas No.

153190-29-5

Purity

≥95%

Formula

C37H50N6O2・C4H4O4

Formula Wt.

726.92

Chemical Name

21-[4-(2,6-Di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]pregna-1,4,9[11]-triene-3,20-dione maleate salt

IUPAC Name

(8S,10S,13S,14S,17S)-17-[2-[4-(2,6-dipyrrolidin-1-ylpyrimidin-4-yl)piperazin-1-yl]acetyl]-10,13-dimethyl-6,7,8,12,14,15,16,17-octahydrocyclopenta[a]phenanthren-3-one

Synonym

U74389G, U-74389G maleate

Solubility

Soluble in DMSO(25 mg/ml) and ethanol (25 mg/ml).

Appearance

White powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

U8000 MSDS PDF

Info Sheet

U8000 Info Sheet PDF

References

Bonatsos V, Kappas I, Birbas K, et al. Effects of U-74389G (21-Lazaroid) and ascorbic acid on liver recovery after acute ischemia and reperfusion in rats. In Vivo. 2015 Sep-Oct; 29(5):585-594. PMID: 26359418.

Tsompos C, Panoulis C, Toutouzas K, et al. The effect of the antioxidant drug “U-74389G” on creatinine levels during ischemia reperfusion injury in rats. Curr Urol. 2016 May; 9(2):73-78. PMID: 27390579.

Margonis GA, Christoloukas N, Antoniou E, et al. Effectiveness of sildenafil and U-74389G in a rat model of colitis. J Surg Res. 2015 Feb; 193(2):667-674. PMID: 25277360.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2023 LKT Laboratories, All Rights Reserved - Products for research use only