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Esculin

Product ID E7310
Cas No. 531-75-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $51.90 In stock
5 g $95.90 In stock
10 g $152.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Esculin is a coumarin glucoside found in Aesculus, Daphne, and Bursaria. Esculin exhibits anti-diabetic and antioxidative activities. Esculin is hydrolyzed by species of Streptococcus, Enterococcus, Listeria, and Aerococcus and is used in research models to identify these bacteria. In diabetic rats, esculin decreases blood glucose and glucose-6-phosphatase levels and increases glucose uptake, potentially through the activation of insulin receptors, Akt, and GSK3β. Additionally, esculin decreases lipid peroxidation and increases levels of glutathione, glutathione peroxidase, glutathione-S-transferase, superoxide dismutase, and catalase in the kidneys of animals treated with pro-oxidant aflatoxin B1.

Product Info

Cas No.

531-75-9

Purity

≥98%

Formula

C15H16O9 • H2O

Formula Wt.

358.30

Chemical Name

6-(β-D-Glucopyranosyloxy)-7-hydroxy-2H-1- benzopyran-2-one

IUPAC Name

7-hydroxy-6-[(2S,3R,4S,5S,6R)-3,4, 5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one

Synonym

Esculin hydrate, Esculoside, Bicolorin, Enallachrome, Polychrome, Escosyl

Melting Point

203-205°C

Solubility

Slightly soluble in water. Soluble in methanol, DMSO (60 mg/mL).

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

E7310 MSDS PDF

Info Sheet

E7310 Info Sheet PDF

References

Kang KS, Lee W, Jung Y, et al. Protective effect of esculin on streptozotocin-induced diabetic renal damage in mice. J Agric Food Chem. 2014 Mar 5;62(9):2069-76. PMID: 24484395.

Naaz F, Abdin MZ, Javed S. Protective effect of esculin against prooxidant aflatoxin B1-induced nephrotoxicity in mice. Mycotoxin Res. 2014 Feb;30(1):25-32. PMID: 24326591.

Raemy A, Meylan M, Casati S, et al. Phenotypic and genotypic identification of streptococci and related bacteria isolated from bovine intramammary infections. Acta Vet Scand. 2013 Jul 18;55:53. PMID: 23866930.

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