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5-Aminosalicylic Acid

Product ID A5035
Cas No. 89-57-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $37.10 In stock
25 g $120.30 In stock
100 g $370.40 In stock
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  • Product Info
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  • Description
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Description

5-Aminosalicylic acid exhibits anti-inflammatory, antioxidative, and anticancer activities; it is clinically used to treat inflammatory bowel disease (IBD), Crohn’s disease, and colitis, as it acts primarily in the colon. In vitro, 5-aminosalicylic acid decreases levels of ROS, increases levels of catalase and PPARγ, and stimulates PTEN signaling. In colorectal cancer cells, this compound decreases proliferation by inhibiting phospholipase D (PLD) activity and mTOR signaling.

Product Info

Cas No.

89-57-6

Purity

≥98%

Formula

C7H7NO3

Formula Wt.

153.14

Chemical Name

5-amino-2-hydroxybenzoic acid

IUPAC Name

5-amino-2-hydroxybenzoic acid

Synonym

5-ASA, Mesalamine, Asacol, Salofalk, 5-amino-2- hydroxybenzoic acid

Melting Point

275-280°C (dec)

Appearance

A white or almost white crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

A5035 MSDS PDF

Info Sheet

A5035 Info Sheet PDF

References

Poh J, Knowles S. Safety of 5-Aminosalicylic Acid Derivatives in Patients with Sensitivity to Acetylsalicylic Acid and Nonsteroidal Anti-inflammatory Drugs. Can J Hosp Pharm. 2014 Jan;67(1):35-8. PMID: 24634525.

Managlia E, Katzman RB, Brown JB, et al. Antioxidant properties of mesalamine in colitis inhibit phosphoinositide 3-kinase signaling in progenitor cells. Inflamm Bowel Dis. 2013 Sep;19(10):2051-60. PMID: 23867870.

Baan B, Dihal AA, Hoff E, et al. 5-Aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer. Gut. 2012 Dec;61(12):1708-15. PMID: 22187071.

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