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Lenalidomide

Product ID L1852
Cas No. 191732-72-6
Purity ≥98%
Product Unit SizeCostQuantityStock
50 mg $47.60 In stock
100 mg $68.10 In stock
250 mg $156.60 In stock
1 g $408.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Lenalidomide displays anti-inflammatory, anti-angiogenic, immunosuppressive, and anticancer chemotherapeutic benefits in the treatment of multiple myeloma and myelodysplastic syndromes associated with chromosome 5q deletions. Lenalidomide is a derivative of thalidomide and is also currently in clinical trials as a potential treatment for several lymphomas and leukemias; like thalidomide, it may inhibit TNF-α and cereblon. In vitro, lenalidomide upregulates both BH3-interacting domain death agonist (BID) and FOS and downregulated NKX2-1, increasing apoptosis and inhibiting cell proliferation. Additionally, this compound inhibits VEGF-induced PI3K-Akt signaling as well as expression of HIF-1α.

Product Info

Cas No.

191732-72-6

Purity

≥98%

Formula

C13H13N3O3

Formula Wt.

259.26

Chemical Name

3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione

IUPAC Name

3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione

Synonym

CC-5013, Revlimid

Solubility

DMSO (≥50 mg/mL). Very slightly soluble in water (≤1 mg/mL).

Appearance

White to light yellow powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

L1852 MSDS PDF

Info Sheet

L1852 Info Sheet PDF

References

Kim K, An S, Cha HJ, et al. Lenalidomide induces apoptosis and alters gene expression in non-small cell lung cancer cells. Oncol Lett. 2013 Feb;5(2):588-592. PMID: 23420263.

Chen Y, Borthakur G. Lenalidomide as a novel treatment of acute myeloid leukemia. Expert Opin Investig Drugs. 2013 Mar;22(3):389-97. PMID: 23316859.

Lu L, Payvandi F, Wu L, et al. The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions. Microvasc Res. 2009 Mar;77(2):78-86. PMID: 18805433.

Vallet S, Palumbo A, Raje N, et al. Thalidomide and lenalidomide: Mechanism-based potential drug combinations. Leuk Lymphoma. 2008 Jul;49(7):1238-45. PMID: 18452080.

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