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DAMGO

Product ID D0025
Cas No. 78123-71-4
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $74.10 In stock
2 mg $126.00 In stock
5 mg $222.50 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
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Description

DAMGO is a synthetic peptide μ-opioid receptor agonist (μOR) that exhibits neuromodulatory and antinociceptive/analgesic activities. DAMGO decreases pain effects in animal models of visceral pain and also decreases motor activity in separate animal models. In vitro and in vivo, DAMGO decreases levels of the glutamate transporter EAAT3 and decreases GABA-A current.

Product Info

Cas No.

78123-71-4

Purity

≥95%

Formula

C26H35N5O6

Formula Wt.

513.0

IUPAC Name

(2S)-2-amino-N-[(2R)-1-[[2-[[(2S)-1-(2-hydroxyethylamino)-1-oxo-3-phenylpropan-2-yl]-methylamino]-2-oxoethyl]amino]-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide

Synonym

DAGO, DAMGE

Solubility

Soluble in water (2 mg/mL).

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

D0025 MSDS PDF

Info Sheet

D0025 Info Sheet PDF

References

Wu Q, Xia S, Lin J, et al. Effects of the altered activity of δ-opioid receptor on the expression of glutamate transporter type 3 induced by chronic exposure to morphine. J Neurol Sci. 2013 Dec 15;335(1-2):174-81. PMID: 24120272.

Alexeeva EV, Nazarova GA, Sudakov SK. Effects of peripheral μ, δ, and Κ-opioid receptor agonists on the levels of anxiety and motor activity of rats. Bull Exp Biol Med. 2012 Sep;153(5):720-1. PMID: 23113268.

Herman MA, Gillis RA, Vicini S, et al. Tonic GABAA receptor conductance in medial subnucleus of the tractus solitarius neurons is inhibited by activation of μ-opioid receptors. J Neurophysiol. 2012 Feb;107(3):1022-31. PMID: 22114164.

Al-Khrasani M, Lackó E, Riba P, et al. The central versus peripheral antinociceptive effects of μ-opioid receptor agonists in the new model of rat visceral pain. Brain Res Bull. 2012 Feb 10;87(2-3):238-43. PMID: 22079588.

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