Description
H89 is an inhibitor of PKA that is used to study the effects of PKA signaling in research models. H89 may also inhibit Rho-associated protein kinase (ROCK), S6K1, MSK1, PKBa, and MAPKAP-K1b.
H89 is an inhibitor of PKA that is used to study the effects of PKA signaling in research models. H89 may also inhibit Rho-associated protein kinase (ROCK), S6K1, MSK1, PKBa, and MAPKAP-K1b.
Cas No. | 127243-85-0 |
---|---|
Purity | ≥98% |
Formula | C20H20BrN3O2S |
Formula Wt. | 446.36 |
Chemical Name | N-(2-[P-Bromocinnamylamino]-ethyl)-5-isoquinolinesulfonmide |
IUPAC Name | N-[2-[[(E)-3-(4-bromophenyl)prop-2-enyl]amino]ethyl]isoquinoline-5- sulfonamide;dihydrochloride |
Synonym | H-89 |
Melting Point | 141-143°C |
Solubility | Soluble in DMSO or ethanol:water (1:1). |
Appearance | White powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Choi S, Kim MY, Joo KY, et al. Modafinil inhibits K(Ca)3.1 currents and muscle contraction via a cAMP-dependent mechanism. Pharmacol Res. 2012 Jul;66(1):51-9. PMID: 22414869.
Rogers RC, Hermann GE. Tumor necrosis factor activation of vagal afferent terminal calcium is blocked by cannabinoids. J Neurosci. 2012 Apr 11;32(15):5237-41. PMID: 22496569.
PORCN inhibitor.
Enalapril metabolite; ACE inhibitor.
Sulfonamide; folate production inhibitor.
Voltage-gated Na+ channel blocker, mAChR antago...
Flavone found in Scutellaria; prolyl oligopepti...
Cyclic hexadepsipeptide mycotoxin produced by C...
Kavalactone originally found in Piper methystic...
AMPK activator.
Endogenous cardiomodulatory peptide; NPR-B agon...
Mycotoxin; F1F0 ATP synthase inhibitor.
Quinolone alkaloid precursor of irinotecan, ori...
Oxazoline; glucocorticoid agonist.
Fibrate; PPARα agonist.
Recombinant HCV antigen fragment.
Cysteine-ITC conjugate, antioxidant.
Promotes degradation of cIAP1
Phallotoxin found in Amanita phalloides; microt...
Lectin found in Canavelia, plant mitogen that b...
Mycotoxin that has structural similarity to est...
Organosulfur found in garlic, binds DNA; inward...