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Diosmin

Diosmin

Product ID D3357
Cas No. 520-27-4
Purity ≥95%
Product Unit SizeCostQuantityStock
1 g $30.70 In stock
5 g $61.10 In stock
25 g $183.60 In stock
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  • Description
  • Product Info
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  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Diosmin is a flavone found in Teucrium that exhibits neuroprotective, cardioprotective, antioxidative, anti-hyperlipidemic, anticancer, chemopreventive, and anti-inflammatory activities. Diosmin alleviates neurological deficits, decreases infarct volume, and upregulates expression of pJAK2, pSTAT3, and Bcl-2 in animal models of cerebral ischemia/reperfusion injury. Diosmin also acts as a radical scavenger and increases antioxidative enzyme activity, improving cardiac function in other animal models. In animal models of retinal ischemia/reperfusion, diosmin decreases retinal edema and extravasation. Additionally, diosmin decreases lipid peroxidation and increases HMG CoA reductase in animal models of myocardial infarction. This compound also inhibits proliferation of hepatocellular carcinoma cells and prevents 2-AAF-induced carcinogenesis in vivo.

Product Info

Cas No.

520-27-4

Purity

≥95%

Formula

C28H32O15

Formula Wt.

608.54

Chemical Name

7-[[6-O-(6-Deoxy-a-L-mannopyranosyl)-β-D-gluco- pyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxy- phenyl)-4H-1-benzopyran-4-one

IUPAC Name

5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4, 5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4, 5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one

Synonym

Diosmil, Diovenor, Flebosmil, Hemerven, Insuven, Litosmil, Tovene, Varinon, Venosmine

Melting Point

274°C (dec)

Appearance

Light Yellow Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

D3357 MSDS PDF

Info Sheet

D3357 Info Sheet PDF

References

Senthamizhselvan O, Manivannan J, Silambarasan T, et al. Diosmin pretreatment improves cardiac function and suppresses oxidative stress in rat heart after ischemia/reperfusion. Eur J Pharmacol. 2014 Aug 5;736:131-7. PMID: 24769512.

Liu X, Zhang X, Zhang J, et al. Diosmin protects against cerebral ischemia/reperfusion injury through activating JAK2/STAT3 signal pathway in mice. Neuroscience. 2014 May 30;268:318-27. PMID: 24680937.

Queenthy SS, John B. Diosmin exhibits anti-hyperlipidemic effects in isoproterenol induced myocardial infarcted rats. Eur J Pharmacol. 2013 Oct 15;718(1-3):213-8. PMID: 24036254.

Tahir M, Rehman MU, Lateef A, et al. Diosmin abrogates chemically induced hepatocarcinogenesis via alleviation of oxidative stress, hyperproliferative and inflammatory markers in murine model. Toxicol Lett. 2013 Jul 18;220(3):205-18. PMID: 23665045.

Tong N, Zhang Z, Zhang W, et al. Diosmin alleviates retinal edema by protecting the blood-retinal barrier and reducing retinal vascular permeability during ischemia/reperfusion injury. PLoS One. 2013 Apr 24;8(4):e61794. PMID: 23637907.

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