• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Zerumbone

Zerumbone

Product ID Z1970
Cas No. 471-05-6
Purity ≥99%
Product Unit SizeCostQuantityStock
10 mg $67.80 In stock
50 mg $277.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Zerumbone is a cyclic sesquiterpene compound found in ginger root. Zerumbone exhibits a wide variety of beneficial properties, including anti-hyperlipidemic, anticancer chemotherapeutic, anti-angiogenic, antioxidative, antinociceptive, and anti-inflammatory activities. In an animal model of nonalcoholic fatty liver disease, zerumbone upregulates expression of PPARα and enzymes involved in lipid oxidation and downregulates expression of fatty acid synthase and lipogenic genes, resulting in decreased total cholesterol and triglyceride levels in plasma and improvements in lipid sensitivity. In several cancer cell lines, zerumbone inhibits expression of VEGF and activity of IKKα and NF-κB and activates caspases 3 and 9 and cleavage of poly(ADP)-ribose polymerase (PARP), resulting in apoptosis and decreased cellular proliferation. In both cellular and animal models, this compound displays antioxidative benefit, activating Nrf2 and increasing expression of heme oxygenase 1 (HO-1), resulting in decreased levels of reactive oxygen species (ROS). In vivo, zerumbone exhibits antinociceptive characteristics and is thought to act through L-arginine-NO-cGMP-PKC-K+ channel pathways and TRPV1 channels. Zerumbone also decreases paw edema and granulomatous tissue formation in animal models of inflammation.

Product Info

Cas No.

471-05-6

Purity

≥99%

Formula

C15H22O

Formula Wt.

218.33

Chemical Name

(2E,6E,10E)-2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one

IUPAC Name

(2E,6E,10E)-2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one

Solubility

DMSO (≥10 mg/mL)

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

Z1970 MSDS PDF

Info Sheet

Z1970 Info Sheet PDF

References

Tsuboi K, Matsuo Y, Shamoto T, et al. Zerumbone inhibits tumor angiogenesis via NF-κB in gastric cancer. Oncol Rep. 2014 Jan;31(1):57-64. PMID: 24220661.

Tzeng TF, Liou SS, Chang CJ, et al. Zerumbone, a Natural Cyclic Sesquiterpene of Zingiber zerumbet Smith, Attenuates Nonalcoholic Fatty Liver Disease in Hamsters Fed on High-Fat Diet. Evid Based Complement Alternat Med. 2013;2013:303061. PMID: 24223615.

Sun Y, Sheng Q, Cheng Y, et al. Zerumbone induces apoptosis in human renal cell carcinoma via Gli-1/Bcl-2 pathway. Pharmazie. 2013 Feb;68(2):141-5. PMID: 23469687.

Weng HY, Hsu MJ, Wang CC, et al. Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells. J Biomed Sci. 2012 Oct 5;19:86. PMID: 23035900.

Shin JW, Ohnishi K, Murakami A, et al. Zerumbone induces heme oxygenase-1 expression in mouse skin and cultured murine epidermal cells through activation of Nrf2. Cancer Prev Res (Phila). 2011 Jun;4(6):860-70. PMID: 21367956.

Perimal EK, Akhtar MN, Mohamad AS, et al. Zerumbone-induced antinociception: involvement of the L-arginine-nitric oxide-cGMP -PKC-K+ ATP channel pathways. Basic Clin Pharmacol Toxicol. 2011 Mar;108(3):155-62. PMID: 20955360.

Sulaiman MR, Perimal EK, Akhtar MN, et al. Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. Fitoterapia. 2010 Oct;81(7):855-8. PMID: 20546845.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S0831

    S-(−)-Schisandrin B

    Found in Schisandra.

    ≥98%
  • M568266

    Mogroside IIIe

    Triterpenoid

    ≥98%
  • Z8401

    Z-VAD-FMK

    Non-specific caspase inhibitor used to prevent ...

    ≥95%
  • D8014

    DU-14

    Steroid sulfatase inhibitor.

    ≥98%
  • C1613

    Cediranib

    VEGFR inhibitor.

    ≥98%
  • I7459

    1-Isothiocyanato-8-(methylsulfinyl)-octane

    ITC found in Nasturtium officinale (watercress)...

    ≥98%
  • A5313

    Andrographolide

    Labdane diterpene found in Andrographis; RLR (R...

    ≥98%
  • E6232

    (−)-Epicatechin Gallate

    Flavanol originally found in Camilla (green tea...

    ≥98%
  • G0106

    Gabapentin

    GABA analog; GABA potentiator, adenosine A1 ago...

    ≥98%
  • F5766

    Forchlorfenuron

    Synthetic cytokinin, plant growth regulator; fi...

    ≥98%
  • I9060

    IWP-2

    PORCN inhibitor.

    ≥98%
  • N7332

    NSI-189

    Stem cell neurogenesis inducer.

    ≥99%
  • R1879

    Retinyl Palmitate

    Vitamin A derivative, palmitic acid ester of re...

    ≥1.70 MIU/g, bio assay
  • I7360

    Isosorbide Mononitrate

    NO donor.

    ≥98%
  • B6800

    Bradykinin Triacetate

    Natriuretic, vasodilatory peptide; B1/2 agonist...

    ≥95%
  • N5669

    Nordihydroguaiaretic Acid

    Phenol found in the creosote bush; 5-lipoxygena...

    ≥99%
  • L0362

    Lapatinib free base

    Inhibitor of EGFR/HER2 (ErbB2).

    ≥99%
  • D1760

    3-Acetyl-deoxynivalenol

    Type A trichothecene mycotoxin produced by Fusa...

    ≥98%
  • M1680

    5-Methoxyindole

    Core structure of melatonin; potential PPARγ a...

    ≥98%
  • K040007

    KB-0742

    CDK9 inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only