Description
Z-VAD-FMK is a non-specific caspase inhibitor used to prevent caspase-mediated apoptosis in vitro. This peptide is primarily used in research models of apoptosis.
Product Info
| Cas No. | 187389-52-2 |
|---|---|
| Purity | ≥95% |
| Formula | C22H30FN3O7 |
| Formula Wt. | 467.49 |
| Chemical Name | N-[(Benzyloxy)carbonyl]-L-valyl-N-[(3S)-5-fluoro-1-methoxy-1,4-dioxo-3-pentanyl]-L-alaninamide |
| IUPAC Name | N-[(Benzyloxy)carbonyl]-L-valyl-N-[(3S)-5-fluoro-1-methoxy-1,4-dioxo-3-pentanyl]-L-alaninamide |
| Synonym | Z-VAD(OMe)-FMK, pan-Caspase Inhibitor, Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone, Benzyloxycarbonyl-Val-Ala-DL-Asp(OMe)-fluoromethylketone, Caspase Inhibitor I |
| Solubility | Soluble in DMSO, acetonitrile, DMF. |
| Appearance | White solid. |
Shipping and Storage
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Burmistrova O, Perdomo J, Simões MF, et al. The abietane diterpenoid parvifloron D from Plectranthus ecklonii is a potent apoptotic inducer in human leukemia cells. Phytomedicine. 2015 Oct 15;22(11):1009-16. PMID: 26407943.
Choi EY, Shin KC, Lee J, et al. Treatment with a Small Synthetic Compound, KMU-193, induces Apoptosis in A549 Human Lung Carcinoma Cells through p53 Up-Regulation. Asian Pac J Cancer Prev. 2015;16(14):5883-7. PMID: 26320467.
Davis DA, Naiman NE, Wang V, et al. Identification of Caspase Cleavage Sites in KSHV Latency-Associated Nuclear Antigen and Their Effects on Caspase-Related Host Defense Responses. PLoS Pathog. 2015 Jul 28;11(7):e1005064. PMID: 26218605.