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IWP-2

Product ID I9060
Cas No. 686770-61-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $81.30 In stock
5 mg $137.60 In stock
10 mg $250.00 In stock
25 mg $472.50 In stock
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  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

IWP-2 is an inhibitor of PORCN that inhibits Wnt signaling, exhibiting anticancer activity. IWP-2 increases activity of caspases 3 and 7, inhibiting proliferation, migration, and invasion of gastric cancer cells and colorectal cancer cells.

Product Info

Cas No.

686770-61-6

Purity

≥98%

Formula

C22H18N4O2S3

Formula Wt.

466.60

Chemical Name

N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide

IUPAC Name

N-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxo-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]acetamide

Synonym

IWP2

Solubility

DMF 22 mg/mL warmed (47.14 mM) DMSO 4 mg/mL warmed (8.57 mM) Water Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

I9060 MSDS PDF

Info Sheet

I9060 Info Sheet PDF

Brochures

WNT Booklet

References

Frewer KA, Sanders AJ, Owen S, et al. A role for WISP2 in colorectal cancer cell invasion and motility. Cancer Genomics Proteomics. 2013 Jul-Aug;10(4):187-96. PMID: 23893926.

Mo ML, Li MR, Chen Z, et al. Inhibition of the Wnt palmitoyltransferase porcupine suppresses cell growth and downregulates the Wnt/β-catenin pathway in gastric cancer. Oncol Lett. 2013 May;5(5):1719-1723. PMID: 23761839.

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