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AS-605240

Product ID A7204
Cas No. 648450-29-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $57.70 In stock
5 mg $115.80 In stock
10 mg $165.50 In stock
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  • Description
  • Product Info
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  • Description
  • Product Info
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  • Downloads
  • References
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Description

AS-605240 is an inhibitor of p110δ PI3K that exhibits anti-inflammatory, immunosuppressive, and anti-diabetic activities. In animal models, AS-605240 inhibits the development of or reverses the progression of experimental autoimmune encephalitis (EAE). AS-605240 also inhibits the development of acute lung injury pathology in animal models through increasing levels of ROS, VEGF, and cytokines and decreasing infiltration of dendritic cells and expression of toll-like receptor 4 (TLR4).

Product Info

Cas No.

648450-29-7

Purity

≥98%

Formula

C12H7N3O2S

Formula Wt.

257.27

IUPAC Name

(5E)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione

Synonym

AS605240

Solubility

DMSO 0.4 mg/mL (1.55 mM) Water Insoluble Ethanol Insoluble

Appearance

Light reddish powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A7204 MSDS PDF

Info Sheet

A7204 Info Sheet PDF

References

Comerford I, Litchfield W, Kara E, et al. PI3Kγ drives priming and survival of autoreactive CD4(+) T cells during experimental autoimmune encephalomyelitis. PLoS One. 2012;7(9):e45095. PMID: 23028778.

Azzi J, Moore RF, Elyaman W, et al. The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes. Diabetes. 2012 Jun;61(6):1509-18. PMID: 22403300.

Kim DI, Kim SR, Kim HJ, et al. PI3K-γ inhibition ameliorates acute lung injury through regulation of IκBα/NF-κB pathway and innate immune responses. J Clin Immunol. 2012 Apr;32(2):340-51. PMID: 22198681.

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