• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
AS-605240

AS-605240

Product ID A7204
Cas No. 648450-29-7
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $63.60 In stock
5 mg $127.70 In stock
10 mg $182.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

AS-605240 is an inhibitor of p110δ PI3K that exhibits anti-inflammatory, immunosuppressive, and anti-diabetic activities. In animal models, AS-605240 inhibits the development of or reverses the progression of experimental autoimmune encephalitis (EAE). AS-605240 also inhibits the development of acute lung injury pathology in animal models through increasing levels of ROS, VEGF, and cytokines and decreasing infiltration of dendritic cells and expression of toll-like receptor 4 (TLR4).

Product Info

Cas No.

648450-29-7

Purity

≥98%

Formula

C12H7N3O2S

Formula Wt.

257.27

IUPAC Name

(5E)-5-(quinoxalin-6-ylmethylidene)-1,3-thiazolidine-2,4-dione

Synonym

AS605240

Solubility

DMSO 0.4 mg/mL (1.55 mM) Water Insoluble Ethanol Insoluble

Appearance

Light reddish powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A7204 MSDS PDF

Info Sheet

A7204 Info Sheet PDF

References

Comerford I, Litchfield W, Kara E, et al. PI3Kγ drives priming and survival of autoreactive CD4(+) T cells during experimental autoimmune encephalomyelitis. PLoS One. 2012;7(9):e45095. PMID: 23028778.

Azzi J, Moore RF, Elyaman W, et al. The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes. Diabetes. 2012 Jun;61(6):1509-18. PMID: 22403300.

Kim DI, Kim SR, Kim HJ, et al. PI3K-γ inhibition ameliorates acute lung injury through regulation of IκBα/NF-κB pathway and innate immune responses. J Clin Immunol. 2012 Apr;32(2):340-51. PMID: 22198681.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T1844

    Telbivudine

    Nucleoside (thymidine) analog; DNA chain termin...

    ≥98%
  • V182705

    Verubecestat

    BACE1 inhibitor

    ≥98%
  • P200000

    PF-3845

    FAAH inhibitor.

    ≥98%
  • F8151

    Fumonisin B3

    Mycotoxin produced by Fusarium fungi that infec...

    ≥98%
  • H965142

    Hydrolyzed Fumonisin B1

    Mycotoxin produced by Fusarium fungi that infec...

    ≥99% by ELSD
  • N3584

    Nivalenol

    Trichothecene mycotoxin produced by Fusarium; p...

    ≥98%
  • R1878

    Retinyl Acetate

    Vitamin A derivative, acetate ester of retinol....

    ≥98%
  • N0068

    Naringenin

    Flavanone found in species of Citrus. Naringen...

    ≥98%
  • E7758

    Etomidate

    GABA-A agonist.

    ≥99%
  • I4659

    Iloperidone

    Benzisoxazole phenylethanone; D2 and 5-HT2A ant...

    ≥99%
  • K6276

    (E)-KPT-330

    CRM1-selective inhibitor of nuclear export.

    ≥99%
  • C1844

    Celastrol

    Triterpene isolated Trypterigium wilfordii; HSP...

    ≥98%
  • P2502

    Phenethyl Glucosinolate Potassium

    Found in cruciferous vegetables.

    ≥97%
  • D1850

    Demethoxycurcumin

    Curcumin derivative; AMPK activator, STAT3 and ...

    ≥98%
  • A7200

    AS-252424

    p110γ PI3K inhibitor, potential TRPC1/5/6 nega...

    ≥98%
  • T9974

    [Asp371]-Tyrosinase (369-377), human

    Proteasome antigen.

    ≥95%
  • F5766

    Forchlorfenuron

    Synthetic cytokinin, plant growth regulator; fi...

    ≥98%
  • N5072

    NMS-1286937

    PLK1 inhibitor.

    ≥98%
  • T3203

    Tianeptine Sodium Hydrate

    μOR and δOR agonist, D2/D3 DA potentiator.

    ≥98%
  • G6803

    Granuliberin R

    Antimicrobial peptide found in amphibians.

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only