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Celastrol

Celastrol

Product ID C1844
Cas No. 34157-83-0
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $97.70 In stock
10 mg $163.40 In stock
25 mg $326.70 In stock
100 mg $867.80 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
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  • References
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Description

Celastrol is a triterpene originally found in Trypterigium wilfordii that exhibits antioxidative, anticancer, anti-inflammatory, and anti-atherosclerotic activities. Celastrol attenuates renal damage by downregulating expression of TNF-α, IL-1β, MCP-1, and NF-κB in animal models of ischemic injury and diabetes. Celastrol also shows anti-atrophic benefit in muscle cells through induction of HSP70 and increases in Akt and ERK1/2 signaling. This compound inhibits LDL-induced oxidative stress in vitro and in vivo. Additionally, celastrol shows potential benefit as a treatment for arthritis, as it increases expression of Bax/Bcl-2 and induces cell cycle arrest and caspase-mediated apoptosis in rheumatoid synovial fibroblasts. Celastrol also acts as a competitive inhibitor of HSP90.

Product Info

Cas No.

34157-83-0

Purity

≥98%

Formula

C29H38O4

Formula Wt.

450.61

Chemical Name

(2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid

IUPAC Name

(2R,4aS,6aS,12bR,14aS,14bR)-10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-2-picenecarboxylic acid

Synonym

Tripterin

Appearance

Orange/Red Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C1844 MSDS PDF

Info Sheet

C1844 Info Sheet PDF

References

Chu C, He W, Kuang Y, et al. Celastrol protects kidney against ischemia-reperfusion-induced injury in rats. J Surg Res. 2013 Aug 13. [Epub ahead of print]. PMID: 23981709.

Gwag T, Park K, Kim E, et al. Inhibition of C2C12 myotube atrophy by a novel HSP70 inducer, celastrol, via activation of Akt1 and ERK1/2 pathways. Arch Biochem Biophys. 2013 Sep 1;537(1):21-30. PMID: 23810294.

Gu L, Bai W, Li S, et al. Celastrol prevents atherosclerosis via inhibiting LOX-1 and oxidative stress. PLoS One. 2013 Jun 17;8(6):e65477. PMID: 23799016.

Xu Z, Wu G, Wei X, et al. Celastrol induced DNA damage, cell cycle arrest, and apoptosis in human rheumatoid fibroblast-like synovial cells. Am J Chin Med. 2013;41(3):615-28. PMID: 23711145.

Kim JE, Lee MH, Nam DH, et al. Celastrol, an NF-κB inhibitor, improves insulin resistance and attenuates renal injury in db/db mice. PLoS One. 2013 Apr 26;8(4):e62068. PMID: 23637966.

Ding QH, Cheng Y, Chen WP, et al. Celastrol, an inhibitor of heat shock protein 90β potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes. Eur J Pharmacol. 2013 May 15;708(1-3):1-7. PMID: 23396231.

Lee JH, Choi KJ, Seo WD, et al. Enhancement of radiation sensitivity in lung cancer cells by celastrol is mediated by inhibition of Hsp90. Int J Mol Med. 2011 Mar;27(3):441-6. PMID: 21249311.

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