• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register

Staurosporine

Product ID S7600
Cas No. 62996-74-1
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $41.20 In stock
5 mg $147.20 In stock
25 mg $353.20 In stock
100 mg $882.90 In stock
Bulk Quote
Add to Wishlist

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Staurosporine is an alkaloid initially produced by Streptomyces that inhibits PKC and other protein kinases. Staurosporine is a precursor in the synthesis of kinase inhibitors K252c and PKC412. This compound exhibits anticancer, anti-parasitic, and anti-protozoan activities. Staurosporine induces apoptosis in hepatocarcinoma cells by decreasing levels of p38 MAPK, pERK, and DNA methyltransferase 3B (DNMT 3B) and increasing levels of pJNK. Staurosporine also causes cell death in Trypanosoma. This compound also inhibits mammalian RNA splicing.

Product Info

Cas No.

62996-74-1

Purity

≥98%

Formula

C28H26N4O3

Formula Wt.

466.5

Synonym

AM-2282

Melting Point

237-239°C

Solubility

Soluble in DMSO (50 mM), ethanol, or methanol (2 mg/mL). Insoluble in water.

Appearance

Off-white Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S7600 MSDS PDF

Info Sheet

S7600 Info Sheet PDF

References

Zhao C, Yin P, Mei C, et al. Down-regulation of DNA methyltransferase 3B in staurosporine-induced apoptosis and its mechanism in human hepatocarcinoma cell lines. Mol Cell Biochem. 2013 Apr;376(1-2):111-9. PMID: 23397112.

Bruges G, Betancourt M, March M, et al. Apoptotic-like activity of staurosporine in axenic cultures of Trypanosoma evansi. Rev Inst Med Trop Sao Paulo. 2012 Mar-Apr;54(2):103-8. PMID: 22499424.

Aukema KG, Chohan KK, Plourde GL, et al. Small molecule inhibitors of yeast pre-mRNA splicing. ACS Chem Biol. 2009 Sep 18;4(9):759-68. PMID: 19634919.

Tanramluk D, Schreyer A, Pitt WR, et al. On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine. Chem Biol Drug Des. 2009 Jul;74(1):16-24. PMID: 19519740.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2023 LKT Laboratories, All Rights Reserved - Products for research use only