LKT Labs

Biochemicals for Life Science Research

Indapamide

Product ID I5414
Cas No. 26807-65-8
Purity ≥98%
Product Unit SizeCostQuantityStock
250 mg $64.90 In stock
1 g $83.40 In stock
5 g $277.70 In stock
Bulk Quote

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Description

Indapamide is a thiazide-like diuretic that exhibits antihypertensive and anti-fibrotic activities. Indapamide is clinically used to treat hypertension and heart failure. Indapamide blocks the slow component of delayed rectifier currents (Kv7.1 and minK), potentially causing QT prolongation. In subjects with diabetes, indapamide decreases urine output and serum K+ and Cl- levels and increases renin activity. In spontaneously hypertensive rats, indapamide prevented increases in systolic blood pressure and the development of myocardial fibrosis without affecting NOS expression and NO levels.

Product Info

Cas No.

26807-65-8
Purity

≥98%
Formula

C16H16ClN3O3S
Formula Wt.

365.84
Chemical Name

3-(Aminosulfonyl)-4-chloro-NN-(2,3-dihydro-2-methyl-1H-indol-1-yl)benzamide
IUPAC Name

4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoylbenzamide
Synonym

S-1520, Bajaten, Fludex, Indamol, Lozol, Natrilix, Veroxil
Melting Point

160-162°C
Solubility

Soluble in methanol, acetic acid and ethyl acetate. Slightly soluble in chloroform.

Appearance

White or off-white crystal powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

I5414 MSDS PDF
Info Sheet

I5414 Info Sheet PDF

References

Janega P, Kojsová S, Jendeková L, et al. Indapamide-induced prevention of myocardial fibrosis in spontaneous hypertension rats is not nitric oxide-related. Physiol Res. 2007;56(6):825-8. PMID: 18197750.

Letsas KP, Alexanian IP, Pappas LK, et al. QT interval prolongation and torsade de pointes associated with indapamide. Int J Cardiol. 2006 Oct 10;112(3):373-4. PMID: 16260053.

Peng H, Zhou Z, Zhao W, et al. Study on the antidiuretic efficacy and mechanism of indapamide in central diabetes insipidus. Hunan Yi Ke Da Xue Xue Bao. 1999;24(3):259-62. PMID: 12016800.

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