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Hypothemycin

Product ID H9862
Cas No. 76958-67-3
Purity ≥96%
Product Unit SizeCostQuantityStock
1 mg $283.40 In stock
5 mg $987.40 In stock
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  • Description
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Description

Hypothemycin is a polyketide found in Setophoma that exhibits anticancer, antifungal, and anti-parasitic activities. Hypothemycin is a resorcyclic acid lactone. This compound inhibits cell survival in melanoma and colon cancer cells. Hypothemycin also disrupts cell wall and endomembrane function in species of Pernophythora and suppresses growth of Trypanosoma in vitro and in vivo.

Product Info

Cas No.

76958-67-3

Purity

≥96%

Formula

C19H22O8

Formula Wt.

378.37

IUPAC Name

(1aR,8S,10Z,13S,14S,15aR)-5,13,14-Trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione

Solubility

DMSO: soluble acetone: soluble water: insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

H9862 MSDS PDF

Info Sheet

H9862 Info Sheet PDF

References

El-Elimat T, Figueroa M, Raja HA, et al. Biosynthetically Distinct Cytotoxic Polyketides from Setophoma terrestris. European J Org Chem. 2015 Jan 1;2015(1):109-121. PMID: 25574154.

Xu L, Xue J, Wu P, et al. Antifungal activity of hypothemycin against Peronophythora litchii in vitro and in vivo. J Agric Food Chem. 2013 Oct 23;61(42):10091-5. PMID: 24106914.

Nishino M, Choy JW, Gushwa NN, et al. Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei [corrected]. Elife. 2013 Jul 9;2:e00712. PMID: 23853713.

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