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10-Deacetyltaxol is a taxane found in Taxus that exhibits nephroprotective and anticancer activities. Like other taxanes, this compound binds tubulin and promotes microtubule assembly, preventing depolymerization. In animal models of polycystic kidney disease, 10-deacetyltaxol inhibits disease progression. This compound also inhibits growth of cervical carcinoma cells, glioblastoma cells, and neuroblastoma cells.
| Cas No. | 78432-77-6 |
|---|---|
| Purity | ≥98% |
| Formula | C45H49NO13 |
| Formula Wt. | 811.87 |
| Synonym | 10-Deacetylpaclitaxel |
| Solubility | Soluble in organic solvents. |
| Appearance | White Powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Ueda JY, Awale S, Tezuka Y, et al. Growth inhibitory activity of wood of Taxus yunnanensis and its liquid chromatography Fourier-transform mass spectrometry analysis. Planta Med. 2006 Oct;72(13):1241-4. PMID: 16902867.
Shen YC, Chen YJ, Chen CY. Taxane diterpenoids from the seeds of Chinese yew Taxus chinensis. Phytochemistry. 1999 Dec;52(8):1565-9. PMID: 10647221.
Woo DD, Tabancay AP Jr, Wang CJ. Microtubule active taxanes inhibit polycystic kidney disease progression in cpk mice. Kidney Int. 1997 May;51(5):1613-8. PMID: 9150481.
Helson L. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol. 1993 Feb;2(2):297-9. PMID: 21573554
