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10-Deacetyltaxol

10-Deacetyltaxol

Product ID T0100
Cas No. 78432-77-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $595.20 In stock
10 mg $952.20 In stock
25 mg $2,045.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

10-Deacetyltaxol is a taxane found in Taxus that exhibits nephroprotective and anticancer activities. Like other taxanes, this compound binds tubulin and promotes microtubule assembly, preventing depolymerization. In animal models of polycystic kidney disease, 10-deacetyltaxol inhibits disease progression. This compound also inhibits growth of cervical carcinoma cells, glioblastoma cells, and neuroblastoma cells.

Product Info

Cas No.

78432-77-6

Purity

≥98%

Formula

C45H49NO13

Formula Wt.

811.87

IUPAC Name

[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9,12-trihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate

Synonym

10-Deacetylpaclitaxel, Deacetyltaxol, 10-Desacetyl Paclitaxel, 10-Deacetylpaclitaxel

Solubility

Soluble in organic solvents.

Appearance

White Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T0100 MSDS PDF

Info Sheet

T0100 Info Sheet PDF

References

Ueda JY, Awale S, Tezuka Y, et al. Growth inhibitory activity of wood of Taxus yunnanensis and its liquid chromatography Fourier-transform mass spectrometry analysis. Planta Med. 2006 Oct;72(13):1241-4. PMID: 16902867.

Shen YC, Chen YJ, Chen CY. Taxane diterpenoids from the seeds of Chinese yew Taxus chinensis. Phytochemistry. 1999 Dec;52(8):1565-9. PMID: 10647221.

Woo DD, Tabancay AP Jr, Wang CJ. Microtubule active taxanes inhibit polycystic kidney disease progression in cpk mice. Kidney Int. 1997 May;51(5):1613-8. PMID: 9150481.

Helson L. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol. 1993 Feb;2(2):297-9. PMID: 21573554

Custom Order

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