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GDC-0068

Product ID G1200
Cas No. 1001264-89-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $110.40 In stock
5 mg $188.20 In stock
25 mg $486.80 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

GDC-0068 is an orally available Akt inhibitor that exhibits chemotherapeutic activity. GDC-0068 prevents Akt from phosphorylating substrates involved in cell proliferation and the inhibition of pro-apoptotic genes and tumor suppressing proteins.

Product Info

Cas No.

1001264-89-6

Purity

≥98%

Formula

C24H32ClN5O2

Formula Wt.

458.00

Chemical Name

(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6, 7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one

IUPAC Name

(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6, 7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2- ylamino)propan-1-one

Synonym

RG7440, Ipatasertib

Solubility

DMSO 92 mg/mL (200.87 mM) Ethanol 92 mg/mL (200.87 mM) Water Insoluble

Appearance

tan powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

G1200 MSDS PDF

Info Sheet

G1200 Info Sheet PDF

References

Davies BR, Greenwood H, Dudley P, et al. Preclinical pharmacology of AZD5363, an inhibitor of AKT: pharmacodynamics, antitumor activity, and correlation of monotherapy activity with genetic background. Mol Cancer Ther. 2012 Apr;11(4):873-87. PMID: 22294718.

Markman B, Dienstmann R, Tabernero J. Targeting the PI3K/Akt/mTOR pathway--beyond rapalogs. Oncotarget. 2010 Nov;1(7):530-43. Review. PubMed PMID: 21317449.

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