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Z-JIB-04

Z-JIB-04

Product ID J3205
Cas No. 199596-24-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $126.50 In stock
25 mg $421.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Z-JIB-04 is the Z stereoisomer of JIB-04, an inhibitor of Jumonji family histone demethylases; it does not inhibit activity of α-ketoglutarate. JIB-04 exhibits anticancer chemotherapeutic activity, inhibiting protein translation initiation. In cancer models, JIB-04 inhibits cell viability, decreases tumor burden, and increases survival rates.

Product Info

Cas No.

199596-24-2

Purity

≥98%

Formula

C17H13ClN4

Formula Wt.

308.77

IUPAC Name

5-Chloro-2-{(2Z)-2-[phenyl(2-pyridinyl)methylene]hydrazino}pyridine

Synonym

NSC 693627

Solubility

DMSO 25 mg/mL Water Insoluble Ethanol Insoluble

Appearance

Light yellow solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

J3205 MSDS PDF

Info Sheet

J3205 Info Sheet PDF

References

Van Rechem C, Black JC, Boukhali M, et al. Lysine demethylase KDM4A associates with translation machinery and regulates protein synthesis. Cancer Discov. 2015 Mar;5(3):255-63. PMID: 25564516.

Wang L, Chang J, Varghese D, et al. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun. 2013;4:2035. Erratum in: Nat Commun. 2013;4:2639. PMID: 23792809.

Custom Order

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