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BAY80-6946 Hydrochloride

BAY80-6946 Hydrochloride

Product ID B0397
Cas No. 1402152-13-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $77.80 In stock
5 mg $162.30 In stock
10 mg $292.00 In stock
50 mg $648.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

BAY80-6946 is an inhibitor of p110α PI3K that exhibits anticancer chemotherapeutic activity. BAY80-6946 is currently in clinical trials and shows some benefit in the treatment of pancreatic cancer. In cellular and animal models of multiple myeloma, BAY80-6946 inhibits cell cycle progression, induces apoptosis, and inhibits cell proliferation and tumor growth.

Product Info

Cas No.

1402152-13-9

Purity

≥98%

Formula

C23H30Cl2N8O4

Formula Wt.

553.45

Chemical Name

2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide;dihydrochloride

IUPAC Name

2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide;dihydrochloride

Synonym

Copanlisib HCl, BAY80-6946 HCl; Copanlisib dihydrochloride; UNII-03ZI7RZ52O; 03ZI7RZ52O

Solubility

Soluble in water (20 mg/mL).

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B0397 MSDS PDF

Info Sheet

B0397 Info Sheet PDF

References

Glauer J, Pletz N, Schön M, et al. A novel selective small-molecule PI3K inhibitor is effective against human multiple myeloma in vitro and in vivo. Blood Cancer J. 2013 Sep 6;3:e141. PMID: 24013662.

Cheng H, Merika E, Syrigos KN, et al. Novel agents for the treatment of pancreatic adenocarcinoma. Highlights from the "2011 ASCO Annual Meeting". Chicago, IL, USA; June 3-7, 2011. JOP. 2011 Jul 8;12(4):334-8. PMID: 21737890.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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