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Purmorphamine

Product ID P8370
Cas No. 483367-10-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $79.00 In stock
5 mg $150.10 In stock
25 mg $589.50 In stock
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  • Product Info
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  • Description
  • Product Info
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Description

Purmorphamine is an agonist at Smoothened (Smo) receptors; it stimulates activity in the Hedgehog signaling pathway. Purmorphamine displays neuroprotective, pro-angiogenic, and anti-osteoporotic activities. In mesenchymal stem cells, this compound decreases proliferation, increases alkaline phosphatase activity, and accelerates osteogenesis. In animal models of stroke, purmorphamine restores neurological deficits, decreases neuronal apoptosis, and increases neovascularization. Purmorphamine also inhibits the induction of autophagy in hepatocellular carcinoma cells.

Product Info

Cas No.

483367-10-8

Purity

≥98%

Formula

C31H32N6O2

Formula Wt.

520.64

IUPAC Name

9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthyloxy)-9H-purin-6-amine

Solubility

100mM in DMSO

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

P8370 MSDS PDF

Info Sheet

P8370 Info Sheet PDF

References

Wöltje M, Böbel M, Heiland M, et al. Purmorphamine and oxysterols accelerate and promote osteogenic differentiation of mesenchymal stem cells in vitro. In Vivo. 2015 Mar-Apr;29(2):247-54. PMID: 25792653.

Chechneva OV, Mayrhofer F, Daugherty DJ, et al. A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury. Cell Death Dis. 2014 Oct 23;5:e1481. PMID: 25341035.

Wang Y, Han C, Lu L, et al. Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells. Hepatology. 2013 Sep;58(3):995-1010. PMID: 23504944.

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