AG-1478 is an inhibitor of EGFR that exhibits anticancer, anti-inflammatory, and anti-asthma activities. AG-1478 inhibits proliferation of hepatocellular carcinoma cells but potential use is limited by poor solubility. In bronchial epithelial cells, this compound decreases goblet cell number and mucus hypersecretion. AG-1478 also suppresses secretion of MUC5AC, VEGF, and IL-8 in airway epithelial cells, potentially preventing airway inflammation and remodeling.
| Cas No. | 153436-53-4 |
|---|---|
| Purity | ≥98% |
| Formula | C16H14ClN3O2 |
| Formula Wt. | 315.76 |
| IUPAC Name | n-(3-chlorphenyl)-6,7-dimethoxy-4-chinazolinamin |
| Synonym | Tyrphostin AG1478, NSC693255 |
| Appearance | White to off white powder |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Parker JC, Douglas I, Bell J, et al. Epidermal Growth Factor Removal or Tyrphostin AG1478 Treatment Reduces Goblet Cells & Mucus Secretion of Epithelial Cells from Asthmatic Children Using the Air-Liquid Interface Model. PLoS One. 2015 Jun 9;10(6):e0129546. PMID: 26057128.
Bondì ML, Azzolina A, Craparo EF, et al. Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells. J Nanobiotechnology. 2014 May 12;12:21. PMID: 24886097.
Shimizu S, Kouzaki H, Ogawa T, et al. Eosinophil-epithelial cell interactions stimulate the production of MUC5AC mucin and profibrotic cytokines involved in airway tissue remodeling. Am J Rhinol Allergy. 2014 Mar-Apr;28(2):103-9. PMID: 24717945.
