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AG-1478

AG-1478

Product ID A2500
Cas No. 153436-53-4
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $58.50 In stock
25 mg $127.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

AG-1478 is an inhibitor of EGFR that exhibits anticancer, anti-inflammatory, and anti-asthma activities. AG-1478 inhibits proliferation of hepatocellular carcinoma cells but potential use is limited by poor solubility. In bronchial epithelial cells, this compound decreases goblet cell number and mucus hypersecretion. AG-1478 also suppresses secretion of MUC5AC, VEGF, and IL-8 in airway epithelial cells, potentially preventing airway inflammation and remodeling.

Product Info

Cas No.

153436-53-4

Purity

≥98%

Formula

C16H14ClN3O2

Formula Wt.

315.76

Chemical Name

N-(3-Chlorophenyl)-6,7-dimethoxyquinazolin-4-amine

IUPAC Name

n-(3-chlorphenyl)-6,7-dimethoxy-4-chinazolinamin

Synonym

Tyrphostin AG1478, NSC693255

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A2500 MSDS PDF

Info Sheet

A2500 Info Sheet PDF

References

Parker JC, Douglas I, Bell J, et al. Epidermal Growth Factor Removal or Tyrphostin AG1478 Treatment Reduces Goblet Cells & Mucus Secretion of Epithelial Cells from Asthmatic Children Using the Air-Liquid Interface Model. PLoS One. 2015 Jun 9;10(6):e0129546. PMID: 26057128.

Bondì ML, Azzolina A, Craparo EF, et al. Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells. J Nanobiotechnology. 2014 May 12;12:21. PMID: 24886097.

Shimizu S, Kouzaki H, Ogawa T, et al. Eosinophil-epithelial cell interactions stimulate the production of MUC5AC mucin and profibrotic cytokines involved in airway tissue remodeling. Am J Rhinol Allergy. 2014 Mar-Apr;28(2):103-9. PMID: 24717945.

Custom Order

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