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Puerarin, High Purity

Puerarin, High Purity

Product ID P8117
Cas No. 3681-99-0
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $155.60 In stock
10 mg $282.20 In stock
25 mg $583.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Puerarin is an isoflavone derivative of daidzein found in Pueraria (Radix); it exhibits anxiolytic, cardioprotective, neuroprotective, and antioxidative activities. This compound also acts as a phytoestrogen. Puerarin acts as an antagonist at 5-HT2C receptors and at the benzodiazepine site on GABA-A receptors. Puerarin increases social interaction time and locomotor activity in animal models of substance withdrawal and inhibits cognitive impairment in the Morris water maze paradigm in animal models of Alzheimer’s disease. Additionally, puerarin decreases systolic blood pressure and heart rate and downregulates expression of P2X3 receptors in animal models of myocardial ischemia/reperfusion. This compound also protects neurons against H2O2-induced oxidative stress in vitro.

Product Info

Cas No.

3681-99-0

Purity

≥99%

Formula

C21H20O9

Formula Wt.

416.38

Chemical Name

8-β-D-glucopyranosyl-7-hydroxy-3- (4-hydroxyphenyl)-(9CI)4H-1-Benzopyran-4-one

IUPAC Name

7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4, 5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one

Melting Point

187°C

Solubility

Soluble in methanol. Slightly soluble in ethanol.

Appearance

White powder with yellow cast

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

P8117 MSDS PDF

Info Sheet

P8117 Info Sheet PDF

References

Liu S, Yu S, Xu C, et al. Puerarin alleviates aggravated sympathoexcitatory response induced by myocardial ischemia via regulating P2X3 receptor in rat superior cervical ganglia. Neurochem Int. 2014 May;70:39-49. PMID: 24657446.

Zhou Y, Xie N, Li L, et al. Puerarin alleviates cognitive impairment and oxidative stress in APP/PS1 transgenic mice. Int J Neuropsychopharmacol. 2014 Apr;17(4):635-44. PMID: 24345484.

Zhang Q, Huang WD, Lv XY, et al. Puerarin protects differentiated PC12 cells from H2O2-induced apoptosis through the PI3K/Akt signalling pathway. Cell Biol Int. 2012 May 1;36(5):419-26. PMID: 22126839.

Overstreet DH, Kralic JE, Morrow AL, et al. NPI-031G (puerarin) reduces anxiogenic effects of alcohol withdrawal or benzodiazepine inverse or 5-HT2C agonists. Pharmacol Biochem Behav. 2003 Jun;75(3):619-25. PMID: 12895679.

Malaivijitnond S, Tingmunnuthum D, Gittarasanee S, et al. Puerarin exhibits weak estrogenic activity in female rats. Fitoterapia. 2010 Sep;81(6):569-576. PMID: 20117180.

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