Description
TGX-221 is an inhibitor of PI3Kβ. It exhibits high selectivity to clear cell renal cell carcinoma with VHL and SETD2 mutations. It also inhibits cell migration and invasion, and induces apoptosis in human glioblastoma cells.
TGX-221 is an inhibitor of PI3Kβ. It exhibits high selectivity to clear cell renal cell carcinoma with VHL and SETD2 mutations. It also inhibits cell migration and invasion, and induces apoptosis in human glioblastoma cells.
Cas No. | 663619-89-4 |
---|---|
Formula | C21H24N4O2 |
Formula Wt. | 364.44 |
IUPAC Name | 9-(1-anilinoethyl)-7-methyl-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one |
Solubility | DMSO 12 mg/mL (32.92 mM) Water Insoluble Ethanol Insoluble |
Appearance | Light Yellow Powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Feng C., Sun Y., PI3Kβ inhibitor TGX221 selectively inhibits renal cell carcinoma cells with both VHL and SETD2 mutations and links multiple pathways. Sci Rep. 5:9465 (2015). PMID: 25853938.
Yang X., Yang J., TGX-221 inhibits proliferation and induces apoptosis in human glioblastoma cells. Oncol Rep. 38(5):2836-2842. PMID: 29048665.
Minor kavalactone originally found in Piper met...
Pyrimidine nucleoside (cytidine) analog; DNA ch...
Alkaloid found in Galanthus, Narcissus, Leucoju...
PDGFR and c-Kit inhibitor.
A peroxisome proliferator-activated receptor ag...
Found in cruciferous vegetables.
Enalapril metabolite; ACE inhibitor.
Camptothecin derivative; topoisomerase I inhibi...
Type A trichothecene mycotoxin produced by Fusa...
H+/K+ ATPase inhibitor.
Bosutinib isomer; Src and Abl inhibitor.
Fluorinated aminopropyl carbazole, neuroprotect...
Tropane alkaloid found in Solanaceae plants; M1...
SIRT2 inhibitor.
Acyl transfer catalyst, involved in peptide syn...
STING antagonist
Flavonoid found in Epimedium.
Coumarin; VKORC1 inhibitor.
Oxazolidinone; protein synthesis inhibitor.