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AZ-628

Product ID A9662
Cas No. 878739-06-1
Purity ≥96%
Product Unit SizeCostQuantityStock
1 mg $92.50 In stock
5 mg $342.80 In stock
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  • Product Info
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
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  • Custom Order

Description

AZ-628 is an irreversible Raf kinase inhibitor that exhibits anticancer chemotherapeutic activity in vitro and in vivo. AZ-628 strongly inhibits tumor cell growth in cells exhibiting mutant (V600E) B-Raf, a mutation commonly found in a variety of cancer subtypes; this compound also inhibits growth in several cell lines that were resistant to most other Raf inhibitors. AZ-628 exhibits similar inhibition of B-Raf and c-Raf in vitro but appears to be selective for B-Raf in vivo.

Product Info

Cas No.

878739-06-1

Purity

≥96%

Formula

C27H25N5O2

Formula Wt.

451.52

Chemical Name

3-(2-cyanopropan-2-yl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)benzamide

IUPAC Name

3-(2-cyanopropan-2-yl)-N-[4-methyl-3-[(3-methyl-4-oxoquinazolin-6-yl) amino]phenyl]benzamide

Solubility

DMSO 90 mg/mL (199.32 mM) Water Insoluble Ethanol Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A9662 MSDS PDF

Info Sheet

A9662 Info Sheet PDF

Brochures

Ras-Raf-MEK-ERK Pathway Booklet

References

Whittaker SR, Theurillat JP, Van Allen E, et al. A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition. Cancer Discov. 2013 Mar;3(3):350-62. PMID: 23288408.

Montagut C, Sharma SV, Shioda T, et al. Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma. Cancer Res. 2008 Jun 15;68(12):4853-61. PMID: 18559533.

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