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Olmesartan Medoxomil

Olmesartan Medoxomil

Product ID O4549
Cas No. 144689-63-4
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $71.50 In stock
100 mg $204.30 In stock
250 mg $357.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Olmesartan medoxomil , a prodrug of Olmesartan, is an angiotensin II type 1 receptor (AT1) inhibitor that inhibits negative regulatory feedback on renin secretion, decreasing secretion of aldosterone and resulting in decreased peripheral vascular resistance (vasodilation). This compound exhibits antihypertensive, cardioprotective, vasodilatory, and anti-inflammatory activities. Due to this action, olmesartan increases cerebral blood flow and cerebrovascular reserve capacity in hypertensive stroke patients. Additionally, this compound improves cardiac function through activation of the DLL4/Notch1 signaling pathway in animal models of chronic cardiac pressure overload. Olmesartan also inhibits activation of apoptosis signal regulating kinase 1 (ASK1) in animal models of diabetes, attenuating cardiac inflammation and vascular endothelial dysfunction.

Product Info

Cas No.

144689-63-4

Purity

≥98%

Formula

C29H30N6O6

Formula Wt.

558.59

Chemical Name

(5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazole-5-carboxylate

IUPAC Name

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl] phenyl]methyl]imidazole-4-carboxylate

Solubility

0.2mg/ml in ethanol, 20mg.ml in DMSO, and 30 mg/ml in DMF, sparingly soluble in aqueous buffers

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

O4549 MSDS PDF

Info Sheet

O4549 Info Sheet PDF

References

You J, Wu J, Jiang G, et al. Olmesartan attenuates cardiac remodeling through DLL4/Notch1 pathway activation in pressure overload mice. J Cardiovasc Pharmacol. 2013 Feb;61(2):142-51. PMID: 23188126.

Verdecchia P, Angeli F, Repaci S, et al. Comparative assessment of angiotensin receptor blockers in different clinical settings. Vasc Health Risk Manag. 2009;5:939-48. PMID: 19997575.

Matsumoto S, Shimodozono M, Miyata R, et al. Benefits of the angiotensin II receptor antagonist olmesartan in controlling hypertension and cerebral hemodynamics after stroke. Hypertens Res. 2009 Nov;32(11):1015-21. PMID: 19745828.

Yamamoto E, Dong YF, Kataoka K, et al. Olmesartan prevents cardiovascular injury and hepatic steatosis in obesity and diabetes, accompanied by apoptosis signal regulating kinase-1 inhibition. Hypertension. 2008 Sep;52(3):573-80. PMID: 18678790.

Brousil JA, Burke JM. Olmesartan medoxomil: an angiotensin II-receptor blocker. Clin Ther. 2003 Apr;25(4):1041-55. PMID: 12809956.

Custom Order

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