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2″,3″-Dihydrocephalomannine

Product ID T0116
Cas No. 159001-25-9
Purity ≥96% (from ≥90%)
Product Unit SizeCostQuantityStock
5 mg $1,220.80 In stock
10 mg $2,177.80 In stock
25 mg $3,815.00 In stock
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  • Description
  • Product Info
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Description

This compound is a derivative of cephalomannine, found in species of Taxus. Like other taxanes, this compound may inhibit DNA polymerase and microtubule depolymerization, exhibiting anticancer activity. Also known as sec-Butyl Analog of Paclitaxel, it is an impurity that may be found when paclitaxel is produced by plant cell fermentation.

Product Info

Cas No.

159001-25-9

Purity

≥96% (from ≥90%)

Formula

C45H55NO14

Formula Wt.

833.92

Chemical Name

[(1S,4S,10S)-4,12-Diacetyloxy-1,9-dihydroxy-15-[2-hydroxy-3-(2-methylbutanoylamino)-3-phenylpropanoyl]oxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate

IUPAC Name

[(1S,4S,10S)-4,12-diacetyloxy-1,9-dihydroxy-15-[2-hydroxy-3-(2-methylbutanoylamino)-3-phenylpropanoyl]oxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate

Synonym

sec-Butyl Analog of Paclitaxel; Dihydrocephalomannine; Paclitaxel - Impurity R; N-Debenzoyl-N-α-methylbutyrylpaclitaxel

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T0116 MSDS PDF

Info Sheet

T0116 Info Sheet PDF

References

Li Y, Qin F, Wang SM, et al. Chemical studies on Taxus canadensis. Chem Biodivers. 2013 Oct;10(10):1729-53. PMID: 24130020.

Oshige M, Takenouchi M, Kato Y, et al. Taxol derivatives are selective inhibitors of DNA polymerase alpha. Bioorg Med Chem. 2004 May 15;12(10):2597-601. PMID: 15110841.

Pandey RC, Yankov LK, Poulev A, et al. Synthesis and separation of potential anticancer active dihalocephalomannine diastereomers from extracts of Taxus yunnanensis. J Nat Prod. 1998 Jan;61(1):57-63. PMID: 9461653.

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