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AZD-8931

Product ID A9813
Cas No. 848942-61-0
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $106.40 In stock
5 mg $252.10 In stock
10 mg $443.00 In stock
25 mg $885.70 In stock
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

AZD-8931 is an inhibitor of EGFR, HER2, and HER3 that exhibits anticancer chemotherapeutic activity. In vitro and in vivo, AZD-8931 suppresses growth of inflammatory breast cancer cells and tumors and induces apoptosis. This compound also inhibits growth in cellular models of non-small cell lung cancer (NSCLC) and squamous cell carcinoma.

Product Info

Cas No.

848942-61-0

Purity

≥98%

Formula

C23H25ClFN5O3

Formula Wt.

473.93

Chemical Name

2-[4-({4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}oxy)-1-piperidinyl]-N-methylacetamide

IUPAC Name

2-[4-({4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}oxy)-1-piperidinyl]-N-methylacetamide

Synonym

AZD8931, Sapitinib

Solubility

DMSO 40 mg/mL Water Insoluble Ethanol Insoluble

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A9813 MSDS PDF

Info Sheet

A9813 Info Sheet PDF

References

Mu Z, Klinowska T, Dong X, et al. AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor (EGFR), HER2, and HER3: preclinical activity in HER2 non-amplified inflammatory breast cancer models. J Exp Clin Cancer Res. 2014 May 30;33:47. PMID: 24886365.

Tjulandin S, Moiseyenko V, Semiglazov V, et al. Phase I, dose-finding study of AZD8931, an inhibitor of EGFR (erbB1), HER2 (erbB2) and HER3 (erbB3) signaling, in patients with advanced solid tumors. Invest New Drugs. 2014 Feb;32(1):145-53. PMID: 23589215.

Hickinson DM, Klinowska T, Speake G, et al. AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockade in cancer. Clin Cancer Res. 2010 Feb 15;16(4):1159-69. PMID: 20145185.

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