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Tulobuterol Hydrochloride

Product ID T8145
Cas No. 56776-01-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $127.90 In stock
5 g $511.20 In stock
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  • Description
  • Product Info
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  • Description
  • Product Info
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  • Downloads
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Description

Tulobuterol is a long-acting β2-adrenergic receptor agonist that is clinically used in some countries to treat chronic obstructive pulmonary disorder (COPD) and asthma. Tulobuterol exhibits bronchodilatory, anti-inflammatory, and antiviral activities. Tulobuterol treats pulmonary disorders by inducing relaxation of airway smooth muscle cells. In tracheal epithelial cells, tulobuterol also prevents activation of NF-κB and decreases levels of ICAM-1, IL-1β, IL-6, and IL-8, inhibiting rhinovirus replication.

Product Info

Cas No.

56776-01-3

Purity

≥98%

Formula

C12H18ClNO • HCl

Formula Wt.

264.19

IUPAC Name

2-(tert-butylamino)-1-(2-chlorophenyl)ethanol

Appearance

White or almost White Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T8145 MSDS PDF

Info Sheet

T8145 Info Sheet PDF

References

Yamaya M, Nishimura H, Nadine L, et al. Tulobuterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. Physiol Rep. 2013 Aug;1(3):e00041. PMID: 24303127.

Katsunuma T, Fujisawa T, Nagao M, et al. Effects of transdermal tulobuterol in pediatric asthma patients on long-term leukotriene receptor antagonist therapy: results of a randomized, open-label, multicenter clinical trial in Japanese children aged 4-12 years. Allergol Int. 2013 Mar;62(1):37-43. PMID: 23000726.

Terpstra GK, Raaijmakers JA. Beta-agonistic properties of tulobuterol, a new beta-sympathicomimetic drug, and its effects on pulmonary beta-adrenoceptor characteristics. Lung. 1990;168 Suppl:179-85. PMID: 1974673.

Ruff F, Zander JF, Edoute Y, et al. Beta-2 adrenergic responses to tulobuterol in airway smooth muscle, vascular smooth muscle and adrenergic nerves. J Pharmacol Exp Ther. 1988 Jan;244(1):173-80. PMID: 2826765.

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