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Erythromycin is a macrolide antibiotic that binds the 50s subunit of bacterial ribosomes, inhibiting protein synthesis by preventing transfer of tRNA from the A site to the P site. This compound displays antibacterial activity against both gram positive and gram negative bacteria; it also inhibits mammalian mRNA splicing.
| Cas No. | 41342-53-4 |
|---|---|
| Purity | ≥97% |
| Formula | C43H75NO16 |
| Formula Wt. | 862.05 |
| Chemical Name | Anamycin |
| IUPAC Name | 4-O-[(2R,3S,4R,6S)-4-(dimethylamino)-2-[[(3R,4S,5S,6R,7R,9R,11R,12R,13S, 14R)-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4, 6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-2, 10-dioxo-oxacyclotetradec-6-yl]oxy]-6-methyloxan-3-yl] 1-O-ethyl butanedioate |
| Synonym | E.E.S., Arpimycin, Durapaediat, E-Mycin E, Eryliquid, Eryped. |
| Melting Point | 109-110°C |
| Solubility | Very slightly soluble in water. Soluble in acetone (500 mg/L), methanol (250 mg/mL), or ethanol (110 mg/mL). |
| Appearance | White crystalline powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| Info Sheet |
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Hertweck M, Hiller R, Mueller MW. Inhibition of nuclear pre-mRNA splicing by antibiotics in vitro. Eur J Biochem. 2002 Jan;269(1):175-83. PMID: 11784311.
Menninger JR, Otto DP. Erythromycin, carbomycin, and spiramycin inhibit protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes. Antimicrob Agents Chemother. 1982 May;21(5):811-8. PMID: 6179465.
