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Sulfamethoxazole is a sulfonamide antibiotic that competitively inhibits PABA, preventing bacterial production of folic acid and synthesis of DNA. Sulfamethoxazole displays antibacterial activity against Streptococcus, Staphylococcus, Escherichia, Haemophilus, and Pneumocystis.
| Cas No. | 723-46-6 |
|---|---|
| Purity | ≥98% |
| Formula | C10H11N3O3S |
| Formula Wt. | 253.28 |
| Chemical Name | 4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfon- amide |
| IUPAC Name | 4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide |
| Synonym | Sulfisomezole, Sulfamethylisoxazole, Sulfamethoxizole, Gantanol, Sinomin |
| Melting Point | 169-172°C |
| Solubility | Insoluble in water. |
| Appearance | White to off white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Jacobs RF, Wilson CB. Intracellular penetration and antimicrobial activity of antibiotics. J Antimicrob Chemother. 1983 Oct;12 Suppl C:13-20. PMID: 6605963.
Gleckman R, Alvarez S, Joubert DW. Drug therapy reviews: trimethoprim-sulfamethoxazole. Am J Hosp Pharm. 1979 Jul;36(7):893-906. PMID: 382841.
Lewis EL, Lacey RW. Present significance of resistance to trimethoprim and sulphonamides in coliforms, Staphylococcus aureus, and Streptococcus faecalis. J Clin Pathol. 1973 Mar;26(3):175-80. PMID: 4633678.
