LKT Labs

Biochemicals for Life Science Research

Losartan Potassium

Product ID L5873
Cas No. 124750-99-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $60.10 In stock
5 g $193.10 In stock
25 g $622.50 In stock
Bulk Quote

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Description

Losartan is an inhibitor of the angiotensin II type 1 (AT1) receptor that exhibits antihypertensive, anti-fibrotic, and nephroprotective activities. In animal models of obstructive nephropathy, losartan decreases levels of α-SMA and collagen type 1 and inhibits phosphorylation of STAT3, suppressing renal tubular fibrosis. Losartan also inhibits the endothelial-to-mesenchymal transition through indirect inhibition of ERK activation, potentially showing anti-fibrotic benefit after myocardial infarction.

Product Info

Cas No.

124750-99-8
Purity

≥98%
Formula

C22H22ClN6O K
Formula Wt.

461.01
Chemical Name

2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'- biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol monopotassium salt
IUPAC Name

potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2, 3-triaza-4-azanidacyclopenta-2, 5-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
Synonym

DuPont-753, Losaprex, Lortaan, Neo-Lotan, Oscaar

Melting Point

263-265°C
Solubility

Soluble in water to 100 mM, DMSO to 100 mM, and alcohol.
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

L5873 MSDS PDF
Info Sheet

L5873 Info Sheet PDF

References

He P, Li D, Zhang B. Losartan attenuates renal interstitial fibrosis and tubular cell apoptosis in a rat model of obstructive nephropathy. Mol Med Rep. 2014 Aug;10(2):638-44. PMID: 24912579.

Wylie-Sears J, Levine RA, Bischoff J. Losartan inhibits endothelial-to-mesenchymal transformation in mitral valve endothelial cells by blocking transforming growth factor-β-induced phosphorylation of ERK. Biochem Biophys Res Commun. 2014 Apr 18;446(4):870-5. PMID: 24632204.

Gibson TJ. Hypertension, its treatment, hyperuricaemia and gout. Curr Opin Rheumatol. 2013 Mar;25(2):217-22. PMID: 23370375.

Apostolakis S, Krambovitis E, Vlata Z, et al. CX3CR1 receptor is up-regulated in monocytes of coronary artery diseased patients: impact of pre-inflammatory stimuli and renin-angiotensin system modulators. Thromb Res. 2007;121(3):387-395. PMID: 17521710.

Koseki N, Deguchi J, Yamashita A, et al. Establishment fo a novel experimental protocol for drug-induced seizure liability screening based on a locomotor activity assay in zebrafish. J Toxicol Sci. 2014 Aug;39(4):579-600. PMID: 25056783.

Nagata T, Fukuzawa T, Takeda M, et al. Tofogliflozin, a novel sodium-glucose co-transporter 2 inhibitor, improves renal and pancreatic function in db/db mice. Br J Pharmacol. 2013 Oct;170(3):519-531. PMID: 23751087.

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