Description
AZD-5438 is a Cdk inhibitor that has been found to be a potent radiosensitizer in non-small cell lung cancer. AZD-5438 has also been shown to inhibit human tumor xenograft growth and reduce the proportion of actively cycling cells.
Product Unit Size | Cost | Quantity | Stock |
---|
AZD-5438 is a Cdk inhibitor that has been found to be a potent radiosensitizer in non-small cell lung cancer. AZD-5438 has also been shown to inhibit human tumor xenograft growth and reduce the proportion of actively cycling cells.
Cas No. | 602306-29-6 |
---|---|
Purity | ≥98% |
Formula | C18H21N5O2S |
Formula Wt. | 371.45 |
Chemical Name | 4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine |
IUPAC Name | 4-(1-Isopropyl-2-methyl-1H-imidazol-5-yl)-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine |
Synonym | AZD5438; MMV676604 |
Solubility | Insoluble in water. Soluble in DMSO (>20 mg/mL). |
Store Temp | 4°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Raghavan P, Tumati V, Yu L, et al. AZD5438, an inhibitor of Cdk1, 2, and 9, enhances the radiosensitivity of non-small cell lung carcinoma cells. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e507-514. PMID: 22795803.
Byth KF, Thomas A, Hughes G, et al. AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. Mol Cancer Ther. 2009 Jul;8(7):1856-1866. PMID: 19509270.
Non-chlorinated analogue of the mycotoxin Ochra...
M3 mAChR antagonist.
ALK inhibitor.
β-adrenergic antagonist, Kv1.4 and K2P2 K+ cha...
Pyrimidine derivative; kinesin Eg5 inhibitor.
Synthesis impurity
Stable salt form of hyperforin, a compound foun...
Triadimefon metabolite; mutagen.
Naphthodianthrone found in Hypericum; dopamine ...
c-Raf inhibitor, tyrosine kinase inhibitor.
5-Lipoxygenase inhibitor.
Benzamide; HDAC1 inhibitor.
Sulfonamide; folate production inhibitor.
Sesquiterpene alcohol found in various essentia...
Derivative of methyl caffeate, hydroxycinnamic ...
Nitrogen mustard, DNA alkylator.
Recombinant protein containing Treponema pallid...
PI3K inhibitor.
Flavanol found in Camilla (green tea); AhR ant...
Smo inhibitor.