• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
AZD-5438

AZD-5438

Product ID A965121
Cas No. 602306-29-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $97.30 In stock
25 mg $382.90 In stock
100 mg $1,161.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

AZD-5438 is a Cdk inhibitor that has been found to be a potent radiosensitizer in non-small cell lung cancer. AZD-5438 has also been shown to inhibit human tumor xenograft growth and reduce the proportion of actively cycling cells.

Product Info

Cas No.

602306-29-6

Purity

≥98%

Formula

C18H21N5O2S

Formula Wt.

371.45

Chemical Name

4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)pyrimidin-2-amine

IUPAC Name

4-(1-Isopropyl-2-methyl-1H-imidazol-5-yl)-N-[4-(methylsulfonyl)phenyl]-2-pyrimidinamine

Synonym

AZD5438; MMV676604

Solubility

Insoluble in water. Soluble in DMSO (>20 mg/mL).

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

A965121 MSDS PDF

Info Sheet

A965121 Info Sheet PDF

References

Raghavan P, Tumati V, Yu L, et al. AZD5438, an inhibitor of Cdk1, 2, and 9, enhances the radiosensitivity of non-small cell lung carcinoma cells. Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e507-514. PMID: 22795803.

Byth KF, Thomas A, Hughes G, et al. AZD5438, a potent oral inhibitor of cyclin-dependent kinases 1, 2, and 9, leads to pharmacodynamic changes and potent antitumor effects in human tumor xenografts. Mol Cancer Ther. 2009 Jul;8(7):1856-1866. PMID: 19509270.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • O0830

    Ochratoxin B

    Non-chlorinated analogue of the mycotoxin Ochra...

    ≥99%
  • D0169

    Darifenacin Hydrobromide

    M3 mAChR antagonist.

    ≥98%
  • A7400

    ASP3026

    ALK inhibitor.

    ≥98%
  • P6852

    Propafenone Hydrochloride

    β-adrenergic antagonist, Kv1.4 and K2P2 K+ cha...

    ≥98%
  • M5752

    Monastrol

    Pyrimidine derivative; kinesin Eg5 inhibitor.

    ≥95%
  • T1028

    Paclitaxel, 8-Hydro-bicyclo(3.3.0)octane

    Synthesis impurity

    ≥95%
  • H9863

    Hyperforin Dicyclohexylammonium

    Stable salt form of hyperforin, a compound foun...

    ≥97%
  • T6831

    Triadimenol

    Triadimefon metabolite; mutagen.

    ≥96%
  • H9861

    Hypericin

    Naphthodianthrone found in Hypericum; dopamine ...

    ≥98%
  • Z4833

    ZM-336372

    c-Raf inhibitor, tyrosine kinase inhibitor.

    ≥98%
  • Z3444

    Zileuton

    5-Lipoxygenase inhibitor.

    ≥98%
  • E5477

    Entinostat

    Benzamide; HDAC1 inhibitor.

    ≥98%
  • S8245

    Sulfadiazine

    Sulfonamide; folate production inhibitor.

    ≥98%
  • F0268

    Farnesol

    Sesquiterpene alcohol found in various essentia...

    ≥98%
  • P2918

    Phenylethyl-4-methylcaffeate

    Derivative of methyl caffeate, hydroxycinnamic ...

    ≥98%
  • C9609

    Cyclophosphamide Monohydrate

    Nitrogen mustard, DNA alkylator.

    ≥98%
  • R3013

    Recombinant TpN 44.50 protein

    Recombinant protein containing Treponema pallid...

    ≥95%
  • L4796

    LY-294002

    PI3K inhibitor.

    ≥99%
  • E6234

    Epigallocatechin Gallate

    Flavanol found in Camilla (green tea); AhR ant...

    ≥98%
  • N859614

    NVP-LDE225

    Smo inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only