LKT Labs

Biochemicals for Life Science Research

Polymyxin B sulfate

Product ID P5747
Cas No. 1405-20-5
Purity ≥6500 iu/mg
Product Unit SizeCostQuantityStock
250 mg $64.90 In stock
1 g $152.40 In stock
5 g $661.50 In stock
Bulk Quote

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Description

Polymyxin B is a mixture of polymyxin B1, B2, B3 and B1-1 sulfates; polymyxin B is a cationic lipid oligopeptide derived from Bacillus polymyxa that displays antibacterial activity against all gram-negative bacteria except species of Proteus. Polymyxin B kills both proliferative and quiescent cells in vitro. Polymyxin B inhibits cellular respiration by inhibiting type II NADH-quinone oxidoreductase activity. This compound also induces aggregation of lipopolysaccharide (LPS) in bacterial cell membranes, altering membrane potential and causing leakage of cellular components. Polymyxin B has been used to treat septic shock induced by LPS of gram-negative bacteria, preventing LPS-induced caspase activity, Fas expression, Bax/Bcl-2 ratio alteration, and apoptosis.

Product Info

Cas No.

1405-20-5
Purity

≥6500 iu/mg
Formula

C56H100N16O17S
Formula Wt.

1301.6
IUPAC Name

N-[4-amino-1-[[1-[[4-amino-1-oxo-1-[[6,9, 18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)- 2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16, 19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1- oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;sulfuric acid
Synonym

Aerosporin
Solubility

Soluble in water (50 mg/mL, hazy solution).
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

P5747 MSDS PDF
Info Sheet

P5747 Info Sheet PDF

References

Deris ZZ, Akter J, Sivanesan S, et al. A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity. J Antibiot (Tokyo). 2013 Oct 30. [Epub ahead of print]. PMID: 24169795.

Zhai B, Lin X. Evaluation of the anticryptococcal activity of the antibiotic polymyxin B in vitro and in vivo. Int J Antimicrob Agents. 2013 Mar;41(3):250-4. PMID: 23313397

Domingues MM, Inácio RG, Raimundo JM, et al. Biophysical characterization of polymyxin B interaction with LPS aggregates and membrane model systems. Biopolymers. 2012;98(4):338-44. PMID: 23193598.

Martin EL, Ranieri VM. Endotoxin removal by polymyxin B immobilized cartridge inactivates circulating proapoptotic factors. Contrib Nephrol. 2010;167:65-76. PMID: 20519900.

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