Sertraline Hydrochloride

Product ID S1971

Cas No. 79559-97-0

Purity ≥98%

Unit Size	Cost	Quantity		Stock

Bulk Quote

Add to Wishlist

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description
Product Info
Shipping and Storage
Downloads
References
Custom Order

Description

Sertraline exhibits antidepressant and anxiolytic activities; it is a typical selective serotonin reuptake inhibitor (SSRI). Sertraline primarily inhibits the 5-HT transporter (SERT), but also inhibits the dopamine transporter (DAT), α1-adrenergic receptors, and potentially σ1 receptors. Additionally, sertraline inhibits osteoclast formation and resorption and induces apoptosis in both osteoclasts and osteoblasts. This compound also acts as a functional inhibitor of acid sphingomyelinase (FIASMA).

Product Info

Cas No.	79559-97-0
Purity	≥98%
Formula	C₁₇H₁₇Cl₂N • HCl
Formula Wt.	342.70
Chemical Name	(1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride
IUPAC Name	(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3, 4-tetrahydronaphthalen-1-amine;hydrochloride
Synonym	Lustral, Zoloft
Melting Point	243-245°C
Solubility	Slightly soluble in water and isopropyl alcohol. Sparingly soluble in ethanol.
Appearance	A White to Off-White Crystalline Powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	S1971 MSDS PDF
Info Sheet	S1971 Info Sheet PDF

References

Guaiana G, Gupta S, Chiodo D, et al. Agomelatine versus other antidepressive agents for major depression. Cochrane Database Syst Rev. 2013 Dec 17;12:CD008851. PMID: 24343836.

Zhu H, Bogdanov MB, Boyle SH, et al. Pharmacometabolomics of response to sertraline and to placebo in major depressive disorder - possible role for methoxyindole pathway. PLoS One. 2013 Jul 17;8(7):e68283. PMID: 23874572.

Hodge JM, Wang Y, Berk M, et al. Selective serotonin reuptake inhibitors inhibit human osteoclast and osteoblast formation and function. Biol Psychiatry. 2013 Jul 1;74(1):32-9. PMID: 23260229.

Meyer JH, Wilson AA, Sagrati S, et al. Serotonin transporter occupancy of five selective serotonin reuptake inhibitors at different doses: an [11C]DASB positron emission tomography study. Am J Psychiatry. 2004 May;161(5):826-35. PMID: 15121647.