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Pramipexole Dihydrochloride

Product ID P6901
Cas No. 191217-81-9
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $92.50 In stock
25 mg $148.20 In stock
100 mg $388.90 In stock
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  • Description
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Description

Pramipexole is an agonist at D2/3 receptors that is clinically used to treat symptoms of Parkinson’s disease. Pramipexole exhibits neuroprotective and antidepressant activities. In animal models, pramipexole decreases immobility time in the forced swim test. In vitro, this compound inhibits LPS-induced degeneration of neurons and also inhibits phosphorylation of α-synuclein.

Product Info

Cas No.

191217-81-9

Purity

≥98%

Formula

C10H17N3S • 2HCl • H2O

Formula Wt.

302.26

Chemical Name

(S)-2-amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride

IUPAC Name

(6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2, 6-diamine;hydrate;dihydrochloride

Melting Point

288-290°C

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P6901 MSDS PDF

Info Sheet

P6901 Info Sheet PDF

References

Chau KY, Cooper JM, Schapira AH. Pramipexole reduces phosphorylation of α-synuclein at serine-129. J Mol Neurosci. 2013 Oct;51(2):573-80. PMID: 23681749.

Kitagawa K, Kitamura Y, Miyazaki T, et al. Effects of pramipexole on the duration of immobility during the forced swim test in normal and ACTH-treated rats. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jul;380(1):59-66. PMID: 19274453.

Iravani MM, Sadeghian M, Leung CC, et al. Continuous subcutaneous infusion of pramipexole protects against lipopolysaccharide-induced dopaminergic cell death without affecting the inflammatory response. Exp Neurol. 2008 Aug;212(2):522-31. PMID: 18571649.

Zarate CA Jr, Payne JL, Singh J, et al. Pramipexole for bipolar II depression: a placebo-controlled proof of concept study. Biol Psychiatry. 2004 Jul 1;56(1):54-60. PMID: 15219473.

Ling ZD, Robie HC, Tong CW, et al. Both the antioxidant and D3 agonist actions of pramipexole mediate its neuroprotective actions in mesencephalic cultures. J Pharmacol Exp Ther. 1999 Apr;289(1):202-10. PMID: 10087005.

Ono K, Takasaki J, Takahashi R, et al. Effects of antiparkinsonian agents on beta-amyloid and alpha-synuclein oligomer formation in vitro. J Neurosci Res. 2013 Oct;91(10):1371-1381. PMID: 23913715.

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