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Polydatin

Product ID P5845
Cas No. 65914-17-2
Purity ≥97%
Product Unit SizeCostQuantityStock
250 mg $61.50 In stock
1 g $116.00 In stock
5 g $231.60 In stock
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  • Product Info
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
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Description

Polydatin is a resveratrol-related glucoside originally found in Polygonum cuspidatum. Polydatin exhibits anticancer, anti-inflammatory, antioxidative, and anti-allergic activities. In lung cancer cells, polydatin downregulates expression of cyclin D1 and Bcl-2 and upregulates expression of Bax, inducing cell cycle arrest and apoptosis. In animal models of sepsis, polydatin decreases sepsis-induced mortality and lung injury by suppressing production of COX-2, iNOS, and inflammatory cytokines. Polydatin also decreases the loss of mucosal barrier integrity in the small intestine due to OVA-induced allergy by inhibiting mast cell degranulation.

Product Info

Cas No.

65914-17-2

Purity

≥97%

Formula

C20H22O8

Formula Wt.

390.38

Chemical Name

3-Hydroxy-5-(2-(4-hydroxyphenyl)ethenyl)phenyl-beta-D-glucoside

IUPAC Name

(2S,3R,4S,5S, 6R)-2-[3-hydroxy-5-[(E)-2-(4-hydroxyphenyl)ethenyl]phenoxy]-6- (hydroxymethyl)oxane-3,4,5-triol

Synonym

Resveratrol 3-β-mono-D-glucoside

Melting Point

223-226°C

Solubility

Soluble in methanol, ethanol acetone, hot water or ethyl acetate.

Appearance

White powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P5845 MSDS PDF

Info Sheet

P5845 Info Sheet PDF

References

Zhang Y, Zhuang Z, Meng Q, et al. Polydatin inhibits growth of lung cancer cells by inducing apoptosis and causing cell cycle arrest. Oncol Lett. 2014 Jan;7(1):295-301. PMID: 24348867.

Yang B, Li JJ, Cao JJ, et al. Polydatin attenuated food allergy via store-operated calcium channels in mast cell. World J Gastroenterol. 2013 Jul 7;19(25):3980-9. PMID: 23840142.

Li XH, Gong X, Zhang L, et al. Protective effects of polydatin on septic lung injury in mice via upregulation of HO-1. Mediators Inflamm. 2013;2013:354087. PMID: 23431240.

Wu MJ, Gong X, Jiang R, et al. Polydatin protects against lipopolysaccharide-induced fulminant hepatic failure in D-galactosamine-sensitized mice. Int J Immunopathol Pharmacol. 2012 Oct-Dec;25(4):923-34. PMID: 23298483.

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