AZ-5104

Name: AZ-5104
SKU: A980005
Availability: InStock

Product ID A980005

Cas No. 1421373-98-9

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

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Description
Product Info
Shipping and Storage
Downloads
References

Description

AZ-5104 is an active metabolite of AZD-9291 (osimertinib), an inhibitor of EGFR. It has shown efficacy in models of non-small cell lung cancer.

Product Info

Cas No.	1421373-98-9
Purity	≥98%
Formula	C₂₇H₃₁N₇O₂
Formula Wt.	485.59
IUPAC Name	N-(2-{[2-(Dimethylamino)ethyl](methyl)amino}-5-{[4-(1H-indol-3-yl)-2-pyrimidinyl]amino}-4-methoxyphenyl)acrylamide
Synonym	AZ-5104, AZ 5104, AZ5104

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	A980005 MSDS PDF
Info Sheet	A980005 Info Sheet PDF

References

Yates J. Ashton S., et al. Irreversible Inhibition of EGFR: Modeling the Combined Pharmacokinetic-Pharmacodynamic Relationship of Osimertinib and Its Active Metabolite AZ5104. Mol Cancer Ther. 15(10):2378-87 (2016). PMID: 27439477.

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