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Bakuchiol

Bakuchiol

Product ID B0109
Cas No. 10309-37-2
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $215.60 In stock
25 mg $431.40 In stock
100 mg $1,389.70 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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Description

Bakuchiol is a prenylated phenolic terpene originally sourced from many plants, including Psoralea coryfolia. Bakuchiol exhibits estrogenic, antibacterial, anti-inflammatory, anti-diabetic, anti-hyperlipidemic, and anti-fibrotic activities. Bakuchiol activates estrogen receptors, displaying preference for ERα over ERβ. Bakuchiol shows antimicrobial activity against species of Streptococcus, Enterococcus, Lactobacillus, Actinomyces, and Porphyromonas. In macrophages, bakuchiol inhibits LPS-induced production of NO and prostaglandin E2 (PGE2); in other cellular models, it decreases formation of leukotriene B4 (LTB4) and thromboxane B2 (TXB2). In vivo, bakuchiol decreases PGE2 levels, myeloperoxidase activity, and neutrophil degranulation, decreasing edema. In multiple animal models of diabetes, this compound decreases plasma glucose and triglyceride levels. Across several cellular models of fibrosis, bakuchiol activates ERK 1/2, JNK, p38 MAPK, caspase-3, cytochrome c release, and cleavage of poly(ADP)-ribose polymerase (PARP). Bakuchiol may also inhibit protein phosphatase 1B (PP1B)

Product Info

Cas No.

10309-37-2

Purity

≥98%

Formula

C18H24O

Formula Wt.

256.38

Chemical Name

Phenol,4-[(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadien-1-yl]

IUPAC Name

4-[(1E,3S)-3-ethenyl-3,7-dimethylocta-1,6-dienyl]phenol

Synonym

Bakuchiol(7CI), Phenol, 4-(3-ethenyl-3,7-dimethyl-1,6-octadienyl)-, [S-(E)]-, Phenol,4-[(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadienyl]- (9CI), (+)-Bakuchiol,(S)-(+)-Bakuchiol, (S)-Bakuchiol, Drupanol, UP 256

Appearance

Yellow liquid

Shipping and Storage

Store Temp

-80°C

Ship Temp

Ambient

Downloads

MSDS

B0109 MSDS PDF

Info Sheet

B0109 Info Sheet PDF

References

Lim SH, Ha TY, Ahn J, et al. Estrogenic activities of Psoralea corylifolia L. seed extracts and main constituents. Phytomedicine. 2011 Mar 15;18(5):425-30. PMID: 21382704.

Choi SY, Lee S, Choi WH, et al. Isolation and anti-inflammatory activity of Bakuchiol from Ulmus davidiana var. japonica. J Med Food. 2010 Aug;13(4):1019-23. PMID: 20553183.

Park EJ, Zhao YZ, Kim YC, et al. Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts. Eur J Pharmacol. 2007 Mar 22;559(2-3):115-23. PMID: 17292878.

Katsura H, Tsukiyama RI, Suzuki A, et al. In vitro antimicrobial activities of bakuchiol against oral microorganisms. Antimicrob Agents Chemother. 2001 Nov;45(11):3009-13. PMID: 11600349.

Krenisky JM, Luo J, Reed MJ, et al. Isolation and antihyperglycemic activity of bakuchiol from Otholobium pubescens (Fabaceae), a Peruvian medicinal plant used for the treatment of diabetes. Biol Pharm Bull. 1999 Oct;22(10):1137-40. PMID: 10549873.

Ferrándiz ML, Gil B, Sanz MJ, et al. Effect of bakuchiol on leukocyte functions and some inflammatory responses in mice. J Pharm Pharmacol. 1996 Sep;48(9):975-80. PMID: 8910867.

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