NSC-74859

Name: NSC-74859
SKU: N7208
Availability: InStock

Product ID N7208

Cas No. 501919-59-1

Purity ≥98%

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Description

NSC-74859 is an inhibitor of pSTAT3 that exhibits anticancer chemotherapeutic, antiviral, anti-fibrotic, and nephroprotective activities. NSC-74859 enhances the toxicity of doxorubicin by inhibiting the epithelial-to-mesenchymal transition (EMT) in vitro; it also enhances the efficacy of cetuximab in hepatic carcinoma cells. In cellular and animal models of hepatocellular cancer, NSC-74859 suppresses cell proliferation and inhibits tumor growth of xenografts. Inhibition of pSTAT3 results in decreased expression of genes encoding cyclin D1, Bcl-xl, and survivin. Additionally, NSC-74859 inhibits replication of varicella-zoster virus (VZV), a herpesvirus. In animal models of kidney injury, NSC-74859 decreases infiltration of inflammatory cells, decreases expression of fibronectin, smooth muscle actin, and collagen type-1 proteins, and inhibits proliferation; together, this increases apoptosis in renal interstitial fibroblasts.

Product Info

Cas No.	501919-59-1
Purity	≥98%
Formula	C₁₆H₁₅NO₇S
Formula Wt.	365.36
Chemical Name	2-Hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid
IUPAC Name	2-hydroxy-4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid
Synonym	S3I-201
Solubility	DMSO: 25 mg/mL

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	N7208 MSDS PDF
Info Sheet	N7208 Info Sheet PDF

References

Kim CK, Ryu WS, Choi IY, et al. Detrimental effects of leptin on intracerebral hemorrhage via the STAT3 signal pathway. J Cereb Blood Flow Metab. 2013 Jun;33(6):944-53. PMID: 23462572.

Hu QD, Chen W, Yan TL, et al. NSC 74859 enhances doxorubicin cytotoxicity via inhibition of epithelial-mesenchymal transition in hepatocellular carcinoma cells. Cancer Lett. 2012 Dec 28;325(2):207-13. PMID: 22781398.

Sen N, Che X, Rajamani J, et al. Signal transducer and activator of transcription 3 (STAT3) and survivin induction by varicella-zoster virus promote replication and skin pathogenesis. Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):600-5. PMID: 22190485.

Chen W, Shen X, Xia X, et al. NSC 74859-mediated inhibition of STAT3 enhances the anti-proliferative activity of cetuximab in hepatocellular carcinoma. Liver Int. 2012 Jan;32(1):70-7. PMID: 22098470.

Pang M, Ma L, Gong R, et al. A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy. Kidney Int. 2010 Aug;78(3):257-68. PMID: 20520592.

Lin L, Amin R, Gallicano GI, et al. The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-beta signaling. Oncogene. 2009 Feb 19;28(7):961-72. PMID: 19137011.

Siddiquee K, Zhang S, Guida WC, et al. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7391-6. PMID: 17463090.