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CKS-17

CKS-17

Product ID C4274
Cas No. 99273-04-8
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $68.30 In stock
1 mg $126.00 In stock
2.5 mg $252.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

CKS-17 is a synthetic peptide with a sequence homologous to endogenous retroviral transmembrane envelope proteins; it exhibits immunosuppressive activity in vitro and in vivo. In one study, CKS-17 inhibits production of IL-12, IL-2, TNF-α, and IFN-γ, increases levels of cAMP and IL-10, and activates ERK1/2, MEK, PKD, PLC-γ, and c-Raf; this results in an inhibition of the Th1-centric immune response.

Product Info

Cas No.

99273-04-8

Purity

≥95%

Formula

C87H148N26O24

Formula Wt.

1942.31

Synonym

Envelope Glycoprotein; Env Polyprotein; CKS 17; CKS17.

Solubility

Soluble in water.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

Info Sheet

C4274 Info Sheet PDF

References

Haraguchi S, Good RA, Day-Good NK. A potent immunosuppressive retroviral peptide: cytokine patterns and signaling pathways. Immunol Res. 2008;41(1):46-55. PMID: 18506644.

Fan Tx, Day NK, Luangwedchakarn V, et al. The phosphorylation of phospholipase C-gamma1, Raf-1, MEK, and ERK1/2 induced by a conserved retroviral peptide. Peptides. 2005 Nov;26(11):2165-74. PMID: 15978701.

Takahashi A, Day NK, Luangwedchakarn V, et al. A retroviral-derived immunosuppressive peptide activates mitogen-activated protein kinases. J Immunol. 2001 Jun 1;166(11):6771-5. PMID: 11359835.

Kabeya H, Ohashi K, Sugimoto C, et al. Bovine leukaemia virus envelope peptides cause immunomodulation in BALB/c mice. Vet Immunol Immunopathol. 1999 Mar 29;68(1):39-48. PMID: 10231950.

Custom Order

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