• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Tirasemtiv

Tirasemtiv

Product ID T3568
Cas No. 1005491-05-3
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $47.30 In stock
5 mg $89.30 In stock
25 mg $189.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tirasemtiv is an activator of the fast skeletal muscle troponin complex that sensitizes the sarcomere to Ca2+ and increases muscle force. Tirasemtiv displays neuromodulatory activity; it improves motor functions in models of amyotrophic lateral sclerosis (ALS) and is currently in clinical trials as a potential treatment for myasthenia gravis and other neurodegenerative diseases.

Product Info

Cas No.

1005491-05-3

Purity

≥99%

Formula

C12H14N4O

Formula Wt.

230.27

IUPAC Name

6-Ethynyl-1-(3-pentanyl)-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one

Synonym

CK-2017357, Troponin Activator

Solubility

DMSO: ≥ 52 mg/mL

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T3568 MSDS PDF

Info Sheet

T3568 Info Sheet PDF

References

Sanders DB, Rosenfeld J, Dimachkie MM, et al. A Double-Blinded, Randomized, Placebo-Controlled Trial to Evaluate Efficacy, Safety, and Tolerability of Single Doses of Tirasemtiv in Patients with Acetylcholine Receptor-Binding Antibody-Positive Myasthenia Gravis. Neurotherapeutics. 2015 Apr;12(2):455-60. PMID: 25742919.

Hwee DT, Kennedy A, Ryans J, et al. Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model. PLoS One. 2014 May 7;9(5):e96921. PMID: 24805850.

Russell AJ, Hartman JJ, Hinken AC, et al. Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases. Nat Med. 2012 Feb 19;18(3):452-5. PMID: 22344294.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T2801

    Thapsigargin

    Sesquiterpene lactone found in Thapsia, used to...

    ≥98%
  • SC7056

    Snake venom – Crotalus durissus terrificus

    Snake venom found in Crotalus durrisus terrific...

    ≥98%
  • B6959

    Bromosporine

    BRD2/4/9 and CECR2 inhibitor.

    ≥99%
  • A2244

    Aflatoxicol

    Mycotoxin, metabolite of aflatoxin B1 produced ...

    ≥98%
  • M9368

    Myristicin

    Allylbenzene found in spices and umbelliferous ...

    ≥98%
  • C0248

    Calcineurin Substrate

    Peptide used to measure in vitro calcineurin ac...

    ≥96%
  • F0150

    Famotidine

    Histamine H2 antagonist, GSK-3β inhibitor.

    ≥98%
  • I1418

    Idebenone

    Synthetic quinone CoQ analog, promotes mitochon...

    ≥98%
  • A6002

    Apamin

    Peptide, bee venom toxin; SK2/3/4 K+ channel bl...

    ≥95%
  • O5212

    Ondansetron Hydrochloride Dihydrate

    5-HT3 antagonist.

    ≥98%
  • A980005

    AZ-5104

    Inhibitor of EGFR.

    ≥98%
  • C0044

    CAL101

    p110δ PI3K inhibitor.

    ≥99%
  • G1869

    Geranylgeraniol

    Diterpene alcohol, geranylgeranyl pyrophosphate...

    ≥85%
  • I5440

    INK128

    mTOR inhibitor.

    ≥99%
  • D4802

    17-Dimethylaminoethylamino Demethoxygeldanamycin

    Geldanamycin derivative; HSP90 inhibitor.

    ≥98%
  • S9754

    Syntide 2

    Synthetic peptide, CDPK, PKC, CaMKII substrate....

    ≥95%
  • A5132

    Amikacin Disulfate

    Aminoglycoside; protein translation inhibitor.<...

    ≥98%
  • T1777

    S,S-(+)-Tetrandrine

    Benzylisoquinoline alkaloid originally found in...

    ≥98%
  • I4802

    Imatinib Mesylate

    Abl, c-Kit, PDGFR inhibitor.

    ≥98%
  • D019601

    Dapagliflozin

    SGLT2 inhibitor

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only