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Tirasemtiv

Product ID T3568
Cas No. 1005491-05-3
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $122.50 In stock
5 mg $428.60 In stock
25 mg $1,301.40 In stock
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  • Description
  • Product Info
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Description

Tirasemtiv is an activator of the fast skeletal muscle troponin complex that sensitizes the sarcomere to Ca2+ and increases muscle force. Tirasemtiv displays neuromodulatory activity; it improves motor functions in models of amyotrophic lateral sclerosis (ALS) and is currently in clinical trials as a potential treatment for myasthenia gravis and other neurodegenerative diseases.

Product Info

Cas No.

1005491-05-3

Purity

≥99%

Formula

C12H14N4O

Formula Wt.

230.27

IUPAC Name

6-Ethynyl-1-(3-pentanyl)-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one

Synonym

CK-2017357, Troponin Activator

Solubility

DMSO: ≥ 52 mg/mL

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T3568 MSDS PDF

Info Sheet

T3568 Info Sheet PDF

References

Sanders DB, Rosenfeld J, Dimachkie MM, et al. A Double-Blinded, Randomized, Placebo-Controlled Trial to Evaluate Efficacy, Safety, and Tolerability of Single Doses of Tirasemtiv in Patients with Acetylcholine Receptor-Binding Antibody-Positive Myasthenia Gravis. Neurotherapeutics. 2015 Apr;12(2):455-60. PMID: 25742919.

Hwee DT, Kennedy A, Ryans J, et al. Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model. PLoS One. 2014 May 7;9(5):e96921. PMID: 24805850.

Russell AJ, Hartman JJ, Hinken AC, et al. Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases. Nat Med. 2012 Feb 19;18(3):452-5. PMID: 22344294.

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