• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
NS-11394

NS-11394

Product ID N7200
Cas No. 951650-22-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $112.60 In stock
5 mg $245.10 In stock
25 mg $844.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

NS-11394 is a positive modulator of GABA-A receptor activity that is somewhat specific for α5/3/2 subunits. This compound exhibits analgesic and anxiolytic activities. In vivo, NS-11394 decreases formalin-induced pain and spinal nerve-ligation-induced mechanical allodynia. NS-11394 also decreases anxiety in animal models, but its use is dose-limited by side effects that include memory impairment.

Product Info

Cas No.

951650-22-9

Purity

≥98%

Formula

C23H19N3O

Formula Wt.

353.43

Chemical Name

3'-[5-(2-Hydroxy-2-propanyl)-1H-benzimidazol-1-yl]-2-biphenylcarbonitrile

IUPAC Name

2-[3-[5-(2-hydroxypropan-2-yl)benzimidazol-1-yl]phenyl]benzonitrile

Synonym

NS11394; UNII-1PTH9FK74J; NS 11394; 1PTH9FK74J

Solubility

DMSO:43mg/ml

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

N7200 MSDS PDF

Info Sheet

N7200 Info Sheet PDF

References

Hofmann M, Kordás KS, Gravius A, et al. Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABA(A) [corrected] receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function. Behav Pharmacol. 2012 Dec;23(8):790-801. Erratum in: Behav Pharmacol. 2013 Apr;24(2):153. PMID: 23075708.

Hansen RR, Erichsen HK, Brown DT, et al. Positive allosteric modulation of GABA-A receptors reduces capsaicin-induced primary and secondary hypersensitivity in rats. Neuropharmacology. 2012 Dec;63(8):1360-7. PMID: 22985969.

Mirza NR, Larsen JS, Mathiasen C, et al. NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a unique subtype-selective GABAA receptor positive allosteric modulator: in vitro actions, pharmacokinetic properties and in vivo anxiolytic efficacy. J Pharmacol Exp Ther. 2008 Dec;327(3):954-68. PMID: 18791063.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • F4556

    Florfenicol

    Synthetic fluorinated thiamphenicol analog; pro...

    ≥98%
  • G1650

    Geniposide

    Iridoid glycoside found in Gardenia.

    ≥98%
  • C0027

    Cafestol Linoleate

    Diterpene found in brewed, unfiltered coffee; F...

    ≥98%
  • T6931

    Triclosan

    Diarylether; bacterial ENR binder, fatty acid s...

    ≥98%
  • E9416

    Exendin-3

    Peptide, GLP-1 analog found in Heloderma; GLP-1...

    ≥95%
  • A2532

    AGI-6780

    Isocitrate dehydrogenase inhibitor.

    ≥98%
  • P1765

    Peptide Standard 1

    For use in amino acid analysis.

    ≥95%
  • A5160

    Ampicillin Trihydrate

    β-lactam; transpeptidase inhibitor.

    ≥97%
  • A5313

    Andrographolide

    Labdane diterpene found in Andrographis; RLR (R...

    ≥98%
  • P6958

    Protopanaxatriol

    Triterpene sapogenin found in species of Panax;...

    ≥95%
  • Z161022

    α-Zearalanol

    Mycotoxin that has structural similarity to est...

    ≥98%
  • C1620

    Ceftiofur Hydrochloride

    β-lactam; penicillin binding protein inhibitor...

    ≥90%
  • P200637

    PF-04745637

    TRPA1 antagonist

    ≥98%
  • A8812

    AWD 131-138

    GABA-A positive modulator.

    ≥99%
  • C8017

    Cuelure

    Hormonal attractant for male Bactrocera flies.<...

    ≥97%
  • A600002

    AP-26113

    Pan inhibitor of ALK.

    ≥98%
  • A7460

    Asparaginase

    Catalyzes hydrolysis of asparagine.

    ≥98%
  • R0248

    Ramatroban

    CRTH2 inhibitor, TxA2 antagonist.

    ≥98%
  • T2932

    Thiamphenicol Glycinate Hydrochloride

    Chloramphenicol derivative; protein translation...

    ≥98%
  • A5032

    D,L-Aminoglutethimide

    Aromatase inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only