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AWD 131-138

AWD 131-138

Product ID A8812
Cas No. 188116-07-6
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $90.50 In stock
5 mg $140.70 In stock
10 mg $265.80 In stock
25 mg $601.80 In stock
50 mg $1,078.50 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
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  • Downloads
  • References
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Description

AWD 131-138 is a positive allosteric modulator of GABA-A receptors; it acts at the benzodiazepine site. AWD 131-138 is used in veterinary medicine to treat canine epilepsy as it displays anticonvulsant and antiepileptic activities. In various animal models, this compound prevents convulsions and the development of epilepsy and increases seizure thresholds.

Product Info

Cas No.

188116-07-6

Purity

≥99%

Formula

C13H14ClN3O2

Formula Wt.

279.72

IUPAC Name

1-(4-Chlorophenyl)-4-(4-morpholinyl)-1,5-dihydro-2H-imidazol-2-one

Synonym

ELB138, ELB-138, ELB 138, Imepitoin

Solubility

10 mM in DMSO

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

A8812 MSDS PDF

Info Sheet

A8812 Info Sheet PDF

References

Rundfeldt C, Löscher W. The pharmacology of imepitoin: the first partial benzodiazepine receptor agonist developed for the treatment of epilepsy. CNS Drugs. 2014 Jan;28(1):29-43. PMID: 24357084.

Löscher W, Hoffmann K, Twele F, et al. The novel antiepileptic drug imepitoin compares favourably to other GABA-mimetic drugs in a seizure threshold model in mice and dogs. Pharmacol Res. 2013 Nov;77:39-46. PMID: 24056205.

Yasar S, Bergman J, Munzar P, et al. Evaluation of the novel antiepileptic drug, AWD 131-138, for benzodiazepine-like discriminative stimulus and reinforcing effects in squirrel monkeys. Eur J Pharmacol. 2003 Apr 4;465(3):257-65. PMID: 12681437.

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