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Mevastatin

Product ID M1685
Cas No. 73573-88-3
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $38.90 In stock
50 mg $147.20 In stock
250 mg $433.80 In stock
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Description

Mevastatin is an HMG-CoA reductase inhibitor that exhibits anti-hyperlipidemic, anticancer, and immunomodulatory activities. Mevastatin induces apoptosis and inhibits growth of salivary adenoid cystic carcinoma cells by increasing cytochrome c release, activation of caspase 3, and phosphorylation of JNK, p38 MAPK, and ERK1/2. In other models, mevastatin inhibits bisphosphonate-induced activation of γδ T cells and release of TNF-α.

Product Info

Cas No.

73573-88-3

Purity

≥98%

Formula

C23H34O5

Formula Wt.

390.51

Chemical Name

(2S)-2-Methylbutanoic acid (1S,7S,8S,8aR)- 1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-[(2R,4R)- tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1- naphthalenyl ester

IUPAC Name

[(1S,7S,8S,8aR)-8-[2-[(2R, 4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8, 8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate

Synonym

Compactin, 6-demethylmevinolin, CS-500, ML-236B.

Melting Point

152°C

Solubility

Soluble in DMSO, or ethanol. Insoluble in water.

Appearance

White Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

M1685 MSDS PDF

Info Sheet

M1685 Info Sheet PDF

Brochures

Statins Flyer

References

Zhang S, Wang XL, Gan YH, et al. Activation of c-Jun N-terminal kinase is required for mevastatin-induced apoptosis of salivary adenoid cystic carcinoma cells. Anticancer Drugs. 2010 Aug;21(7):678-86. PMID: 20629200.

Thompson K, Rogers MJ. Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro. J Bone Miner Res. 2004 Feb;19(2):278-88. PMID: 14969398.

Endo A, Kuroda M, Tsujita Y. ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinium. J Antibiot (Tokyo). 1976 Dec;29(12):1346-8. PMID: 1010803.

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