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Farnesol

Farnesol

Product ID F0268
Cas No. 4602-84-0
Purity ≥98%
Product Unit SizeCostQuantityStock
50 ml $207.50 In stock
100 ml $335.60 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Farnesol is a sesquiterpene alcohol produced from isoprene units; it is found in many essential plant oils as it regulates the volatility of odorants in perfumes. Farnesol exhibits anticancer, chemopreventive, and antifungal activities. In pancreatic adenocarcinoma cells, farnesol induces G0/G1 phase cell cycle arrest, downregulates expression of cyclin A, cyclin B1, and CDK2, and increases expression of p21 and p27. Farnesol also increases latency to tumor formation and decreases tumor incidence in TPA-induced skin carcinogenesis models. Additionally, this compound induces apoptosis and increases ROS formation, inhibiting growth of Aspergillus and Candida.

Product Info

Cas No.

4602-84-0

Purity

≥98%

Formula

C15H26O

Formula Wt.

222.37

Chemical Name

3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol

IUPAC Name

(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol

Melting Point

<25°C

Solubility

Insoluble in water.

Appearance

Clear, very light yellow, slightly viscous liquid

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

F0268 MSDS PDF

Info Sheet

F0268 Info Sheet PDF

References

Wang X, Wang YZ, Zhou Y, et al. Farnesol induces apoptosis-like cell death in the pathogenic fungus Aspergillus flavus. Mycologia. 2014 Jun 3. [Epub ahead of print]. PMID: 24895430.

Zhu J, Krom BP, Sanglard D, et al. Farnesol-induced apoptosis in Candida albicans is mediated by Cdr1-p extrusion and depletion of intracellular glutathione. PLoS One. 2011;6(12):e28830. PMID: 22205973.

Chaudhary SC, Alam MS, Siddiqui MS, et al. Chemopreventive effect of farnesol on DMBA/TPA-induced skin tumorigenesis: involvement of inflammation, Ras-ERK pathway and apoptosis. Life Sci. 2009 Jul 31;85(5-6):196-205. PMID: 19470390.

Wiseman DA, Werner SR, Crowell PL. Cell cycle arrest by the isoprenoids perillyl alcohol, geraniol, and farnesol is mediated by p21(Cip1) and p27(Kip1) in human pancreatic adenocarcinoma cells. J Pharmacol Exp Ther. 2007 Mar;320(3):1163-70. PMID: 17138864.

Custom Order

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