Sumatriptan Succinate

Name: Sumatriptan Succinate
SKU: S8151
Availability: InStock

Product ID S8151

Cas No. 103628-48-4

Purity ≥99%

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Product Info
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References

Description

Sumatriptan is a tryptamine agonist at 5-HT1B/1D receptors that is clinically used to treat migraines. Sumatriptan exhibits vasoconstrictive and gastrointestinal motility modulating activities. The anti-migraine activity of sumatriptan is likely due to its vasoconstrictive activity and ability to decrease the release of substance P and CGRP. Sumatriptan also increases gastric relaxation and delays gastric emptying. Additionally, this compound inhibits 5-HT- and capsaicin-induced signaling of transient receptor potential vanilloid (TRPV1) channels and release of CGRP in vitro and in vivo.

Product Info

Cas No.	103628-48-4
Purity	≥99%
Formula	C₁₄H₂₁N₃O₂S • C₄H₆O₄
Formula Wt.	413.49
Chemical Name	3-[2-(Dimethyl-amin)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate; GR-43175C
IUPAC Name	butanedioic acid;1-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N- methylmethanesulfonamide
Melting Point	165-166°C
Appearance	White to off white powder

Shipping and Storage

Store Temp	Ambient
Ship Temp	Ambient

Downloads

MSDS	S8151 MSDS PDF
Info Sheet	S8151 Info Sheet PDF

References

Blumenfeld A, Gennings C, Cady R. Pharmacological synergy: the next frontier on therapeutic advancement for migraine. Headache. 2012 Apr;52(4):636-47. PMID: 22221151.

Loyd DR, Weiss G, Henry MA, et al. Serotonin increases the functional activity of capsaicin-sensitive rat trigeminal nociceptors via peripheral serotonin receptors. Pain. 2011 Oct;152(10):2267-76. PMID: 21737202.

Muñoz-Islas E, Lozano-Cuenca J, González-Hernández A, et al. Spinal sumatriptan inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors. Eur J Pharmacol. 2009 Aug 1;615(1-3):133-8. PMID: 19460365.

Moro E, Crema F, De Ponti F, et al. Triptans and gastric accommodation: pharmacological and therapeutic aspects. Dig Liver Dis. 2004 Jan;36(1):85-92. PMID: 14971822.