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Ciglitazone

Product ID C3210
Cas No. 74772-77-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $64.90 In stock
5 mg $185.30 In stock
25 mg $740.80 Please Inquire
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  • Product Info
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  • Description
  • Product Info
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  • Downloads
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Description

Ciglitazone is a thiazolidinedione that exhibits antihypertensive, anticancer, and anti-diabetic activities. Ciglitazone acts as an agonist at PPARγ receptors, decreasing insulin levels, VEGF production, and blood pressure. In cellular models of stomach cancer, ciglitazone induces G1 phase cell cycle arrest, inhibits ERK phosphorylation, and suppresses cell growth.

Product Info

Cas No.

74772-77-3

Purity

≥98%

Formula

C18H23NO3S

Formula Wt.

333.45

Chemical Name

(+/-)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione

IUPAC Name

5-[[4-[(1-methylcyclohexyl)methoxy]phenyl]methyl]-1,3-thiazolidine-2, 4-dione

Melting Point

114-130°C

Solubility

Soluble in DMSO or ethanol.

Appearance

Tan solid

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C3210 MSDS PDF

Info Sheet

C3210 Info Sheet PDF

References

Shah DK, Menon KM, Cabrera LM, et al. Thiazolidinediones decrease vascular endothelial growth factor (VEGF) production by human luteinized granulosa cells in vitro. Fertil Steril. 2010 Apr;93(6):2042-7. PMID: 19342033.

Cheon CW, Kim DH, Kim DH, et al. Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20. PMID: 19140230.

Pershadsingh HA, Szollosi J, Benson S, et al. Effects of ciglitazone on blood pressure and intracellular calcium metabolism. Hypertension. 1993 Jun;21(6 Pt 2):1020-3. PMID: 8505086.

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