• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register

Cetirizine Dihydrochloride

Product ID C1876
Cas No. 83881-52-1
Purity ≥99%
Product Unit SizeCostQuantityStock
1 g $44.00 In stock
5 g $117.50 In stock
10 g $186.90 In stock
25 g $326.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Cetirizine is a second generation antihistamine that exhibits anti-inflammatory, immunomodulatory, and anti-allergic activities. Cetirizine inhibits histamine H1 receptors and is used to treat dermatitis in clinical settings. In vitro, cetirizine inhibits DNA binding activity of NF-κB, inhibits expression of adhesion molecules on immunocytes and endothelial cells, and inhibits production of IL-8 and leukotriene B4 (LTB4); this compound also increases release of prostaglandin E2 (PGE2), which suppresses antigen presentation and expression of MHC II on macrophages and decreases tryptase in mast cells.

Product Info

Cas No.

83881-52-1

Purity

≥99%

Formula

C21H25ClN2O3 • 2HCl

Formula Wt.

461.82

Chemical Name

2-[2-[4-[(4-chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]acetic acid

IUPAC Name

2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid;dihydrochloride

Melting Point

210-218°C

Solubility

Soluble in water & Methanol

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

C1876 MSDS PDF

Info Sheet

C1876 Info Sheet PDF

References

Namazi MR. Cetirizine and allopurinol as novel weapons against cellular autoimmune disorders. Int Immunopharmacol. 2004 Mar;4(3):349-53. PMID: 15037212.

Bruno G, Andreozzi P, Magrini L, et al. Serum tryptase in allergic rhinitis: effect of cetirizine treatment. Int J Immunopathol Pharmacol. 2001 Sep-Dec;14(3):147-152. PMID: 12604015.

Slater JW, Zechnich AD, Haxby DG. Second-generation antihistamines: a comparative review. Drugs. 1999 Jan;57(1):31-47. PMID: 9951950.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2023 LKT Laboratories, All Rights Reserved - Products for research use only