Description
Darunavir is an antiviral bioactive small molecule used in the prevention and treatment of HIV and AIDS.
Darunavir
Product ID D022705
Cas No. 206361-99-1
Purity ≥99%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 206361-99-1 |
|---|---|
| Purity | ≥99% |
| Formula | C27H37N3O7S |
| Formula Wt. | 547.67 |
| Chemical Name | [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate |
| IUPAC Name | [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate |
| Synonym | Prezista, TMC 114, TMC-114, TMC114, UIC 94017, Darunavirum |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Darwish I, Al-Majed A, Alsaif N, et al. Darunavir: a comprehensive profile. Profiles Drug Subst Excip Relat Methodol. 2021;46:1-50. PMID: 33461696.
El-Atrouni W, Temesgen Z. Darunavir. Drugs Today (Barc). 2007 Oct;43(10):671-679. PMID: 17987220.
Coffinier C, Hudon S, Lee R, et al. A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells. J Biol Chem. 2008 Apr 11;283(15):9797-9804. PMID: 18230615.
Taura M, Kariya R, Kudo E, et al. Camparative analysis of ER stress response into HIV protease inhibitors: lopinavir but not darunavir induces potent ER stress response via ROS/JNK pathway. Free Radic Biol Med. 2013 Dec;65:778-788. PMID: 23973637.
Berginc K, Milisav I, Kristl A. Garlic flavonoids and organosulfur compounds: impact on the hepatic pharmacokinetics of saquinavir and darunavir. Drug Metab Pharmacokinet. 2010;25(6):521-530. PMID: 20930421.
Berginc K, Trontelj J, Kristl A. The influence of aged garlic extract on the uptake of saquinavir and darunavir into HepG2 cells and rat liver slices. Drug Metab Pharmacokinet. 2010;25(3):307-313. PMID: 20610890.